KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0053 | - |
NADPH | - |
Homo sapiens | |
0.0092 | - |
NADP+ | - |
Homo sapiens | |
0.12 | - |
L-malate | with NADP+ as cosubstrate | Homo sapiens | |
0.96 | - |
L-malate | with NAD+ as cosubstrate | Homo sapiens | |
4.6 | - |
NAD+ | - |
Homo sapiens | |
5.9 | - |
pyruvate | - |
Homo sapiens | |
27.9 | - |
CO2 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
63000 | - |
4 * 63000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
56.35 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + NAD+ | at 39% of the activity with NADP+ | Homo sapiens | pyruvate + CO2 + NADH | - |
ir | |
(S)-malate + NADP+ | the reverse reaction is catalyzed at 84% of the activity | Homo sapiens | pyruvate + CO2 + NADPH | - |
r | |
Oxaloacetate | at 1.3% of the rate of NADP+-linked oxidative decarboxylation | Homo sapiens | Pyruvate + CO2 | - |
? | |
pyruvate + CO2 + NADPH | at 84% of the activity of the NADP+-linked oxidative decarboxylation of malate | Homo sapiens | L-malate + NADP+ | - |
r | |
pyruvate + CO2 + NADPH | - |
Homo sapiens | (S)-malate + NADP+ | - |
r | |
pyruvate + NADPH | at 5.4% of the activity of NADP-dependent oxidative decarboxylation of malate | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 63000, SDS-PAGE | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.1 | - |
NADP+-linked decarboxylation of malate, at 0.2 mM malate | Homo sapiens |
7.3 | - |
carboxylation of pyruvate | Homo sapiens |
7.3 | - |
NADP+-linked decarboxylation of malate, at 1 mM malate | Homo sapiens |
8 | - |
NADP+-linked decarboxylation of malate, at 10 mM malate | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | cofactor | Homo sapiens | |
NADPH | cofactor | Homo sapiens |