Literature summary for 1.1.1.383 extracted from

Wu, W.; Tran-Gyamfi, M.; Jaryenneh, J.; Davis, R.
Cofactor engineering of ketol-acid reductoisomerase (IlvC) and alcohol dehydrogenase (YqhD) improves the fusel alcohol yield in algal protein anaerobic fermentation (2016), Algal Res., 19, 162-167.

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Application

Application	Comment	Organism
biofuel production	combination of high activity alcohol dehydrogenase YqhD mutants with IlvC mutants, both accepting NADH as a redox cofactor, in an engineered Escherichia coli strain, enabling comprehensive utilization of the biomass for biofuel applications. The refined strain, shows an increased fusel alcohol yield of about 60% compared to wild type under anaerobic fermentation on amino acid mixtures.When applied to real algal protein hydrolysates, the strain produces 100% and 38% more total mixed alcohols than the wild type strain on two different algal hydrolysates, respectively	Escherichia coli

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
A71S/R76D/S78D/Q110V	strain engineered to switch the cofactor specificity fromNADPH to NADH, application in an engineered Escherichia coli strain, enabling comprehensive utilization of the biomass for biofuel applications	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P05793	-	-

Synonyms

Synonyms	Comment	Organism
ilvC	-	Escherichia coli

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Release 2023.1 (January 2023)