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Literature summary for 1.1.1.37 extracted from
- Function of cytoplasmic NAD-dependent malate dehydrogenase from rat myocardium under conditions of ischemia (2005), Bull. Exp. Biol. Med., 140, 25-28.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | decreases activity under normal and pathological conditions | Rattus norvegicus |  |
| Cu2+ | 0.01-0.4 mM, activity from ischemic tissue decreases more significantly compared to the control | Rattus norvegicus | |
| Fe2+ | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
oxaloacetate | normal rats | Rattus norvegicus | |
| 0.05 | - |
oxaloacetate | ischemic rats | Rattus norvegicus | |
| 0.05 | - |
NADH | normal rats | Rattus norvegicus | |
| 0.075 | - |
NADH | ischemic rats | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| myocardium | activity decreases 2.7times in myocardium of rats with experimental ischemia. Ischemic tissue damage is accompanied by changes in activity and kinetic and regulatory characteristics of cytoplasmic NAD-MDH from rat heart. It probably results from conformational changes in the enzyme molecule during generation and activation of reactive oxygen species of free radical processes | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| oxaloacetate + NADH + H+ | - |
Rattus norvegicus | (S)-malate + NAD+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NAD-MDH | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8.2 | reduiction of oxaloacetate, enzyme from ischemic rats | Rattus norvegicus |
| 7.2 | 7.8 | reduction of oxaloacetate, enzyme from normal rats | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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