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Literature summary for 1.1.1.37 extracted from

  • Eprintsev, A.T.; Falaleeva, M.I.; Parfyonova, N.V.
    Malate dehydrogenase from the thermophilic bacterium Vulcanithermus medioatlanticus (2005), Biochemistry, 70, 1027-1030.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
citrate competitive with respect to oxaloacetate Vulcanithermus mediatlanticus
Mn2+ 2-40 mM Vulcanithermus mediatlanticus
oxaloacetate
-
Vulcanithermus mediatlanticus
Zn2+ 0.05-0.5 mM Vulcanithermus mediatlanticus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0014
-
NADH
-
Vulcanithermus mediatlanticus
0.048
-
oxaloacetate
-
Vulcanithermus mediatlanticus
0.4
-
NAD+
-
Vulcanithermus mediatlanticus
1.7
-
malate
-
Vulcanithermus mediatlanticus

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ 4-40 mM, activates Vulcanithermus mediatlanticus
Ca2+ 4-40 mM, activates Vulcanithermus mediatlanticus
Mg2+ 4-40 mM, activates Vulcanithermus mediatlanticus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
x * 55000, SDS-PAGE Vulcanithermus mediatlanticus
128000
-
gel filtration Vulcanithermus mediatlanticus

Organism

Organism UniProt Comment Textmining
Vulcanithermus mediatlanticus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Vulcanithermus mediatlanticus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.94
-
-
Vulcanithermus mediatlanticus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Vulcanithermus mediatlanticus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Vulcanithermus mediatlanticus oxaloacetate + NADH + H+
-
?

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Vulcanithermus mediatlanticus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
82
-
-
Vulcanithermus mediatlanticus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
60 90 60°C: about 45% of maximal activity, 90°C: about 60% of maximal activity Vulcanithermus mediatlanticus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
15 min, stable Vulcanithermus mediatlanticus
60
-
15 min, about 25% loss of activity Vulcanithermus mediatlanticus
70
-
15 min, about 50% loss of activity Vulcanithermus mediatlanticus
80
-
15 min, about 70% loss of activity Vulcanithermus mediatlanticus
85
-
1 min, complete loss of activity Vulcanithermus mediatlanticus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
reduction of oxaloacetate Vulcanithermus mediatlanticus
8.5
-
oxidation of malate Vulcanithermus mediatlanticus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0205
-
citrate
-
Vulcanithermus mediatlanticus
0.37
-
Zn2+
-
Vulcanithermus mediatlanticus
2.1
-
oxaloacetate
-
Vulcanithermus mediatlanticus
2.5
-
Mn2+
-
Vulcanithermus mediatlanticus