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Literature summary for 1.1.1.37 extracted from

  • Van Kuijk, B.L.M.; Stams, A.J.M.
    Purification and characterization of malate dehydrogenase from the syntrophic propionate-oxidizing bacterium strain MPOB (1996), FEMS Microbiol. Lett., 144, 141-144.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
oxaloacetate
-
Syntrophobacter fumaroxidans
oxaloacetate
-
Thermus thermophilus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
NADH
-
Syntrophobacter fumaroxidans
0.05
-
oxaloacetate
-
Syntrophobacter fumaroxidans
1.1
-
NAD+
-
Syntrophobacter fumaroxidans
4
-
L-malate
-
Syntrophobacter fumaroxidans

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-
mitochondrion
-
Mus musculus 5739
-
mitochondrion
-
Thermus thermophilus 5739
-
mitochondrion
-
Citrullus lanatus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
2 * 35000, SDS-PAGE Syntrophobacter fumaroxidans
68000
-
gel filtration Syntrophobacter fumaroxidans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
malate + NAD+ Bacillus subtilis
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Mus musculus
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Thermus thermophilus
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Escherichia coli
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Geobacillus stearothermophilus
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Methanothermus fervidus
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Streptosporangium roseum
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Citrullus lanatus
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Chlorobaculum tepidum
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Syntrophobacter fumaroxidans
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Planomonospora venezuelensis
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Streptomyces atratus
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Phenylobacterium immobile
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Prosthecochloris vibrioformis
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Heliomicrobium gestii
-
oxaloacetate + NADH + H+
-
r
malate + NAD+ Syntrophobacter fumaroxidans MPOB
-
oxaloacetate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Chlorobaculum tepidum
-
-
-
Citrullus lanatus
-
watermelon
-
Escherichia coli
-
-
-
Geobacillus stearothermophilus
-
-
-
Heliomicrobium gestii
-
-
-
Methanothermus fervidus
-
-
-
Mus musculus
-
mouse
-
Phenylobacterium immobile
-
-
-
Planomonospora venezuelensis
-
-
-
Prosthecochloris vibrioformis
-
-
-
Streptomyces atratus
-
-
-
Streptosporangium roseum
-
-
-
Syntrophobacter fumaroxidans
-
DSM 10017
-
Syntrophobacter fumaroxidans MPOB
-
DSM 10017
-
Thermus thermophilus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus
-
Thermus thermophilus
-
Escherichia coli
-
Streptosporangium roseum
-
Citrullus lanatus
-
Chlorobaculum tepidum
-
Syntrophobacter fumaroxidans
-
Planomonospora venezuelensis
-
Streptomyces atratus
-
Prosthecochloris vibrioformis
-
Heliomicrobium gestii

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1728
-
-
Syntrophobacter fumaroxidans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Bacillus subtilis oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Mus musculus oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Thermus thermophilus oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Escherichia coli oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Geobacillus stearothermophilus oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Methanothermus fervidus oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Streptosporangium roseum oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Citrullus lanatus oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Chlorobaculum tepidum oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Syntrophobacter fumaroxidans oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Planomonospora venezuelensis oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Streptomyces atratus oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Phenylobacterium immobile oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Prosthecochloris vibrioformis oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Heliomicrobium gestii oxaloacetate + NADH + H+
-
r
(S)-malate + NAD+
-
Syntrophobacter fumaroxidans MPOB oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Bacillus subtilis oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Mus musculus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Thermus thermophilus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Escherichia coli oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Geobacillus stearothermophilus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Methanothermus fervidus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Streptosporangium roseum oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Citrullus lanatus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Chlorobaculum tepidum oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Syntrophobacter fumaroxidans oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Planomonospora venezuelensis oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Streptomyces atratus oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Phenylobacterium immobile oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Prosthecochloris vibrioformis oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Heliomicrobium gestii oxaloacetate + NADH + H+
-
r
malate + NAD+
-
Syntrophobacter fumaroxidans MPOB oxaloacetate + NADH + H+
-
r
oxaloacetate + NADH
-
Bacillus subtilis L-malate + NAD+
-
r
oxaloacetate + NADH
-
Mus musculus L-malate + NAD+
-
r
oxaloacetate + NADH
-
Thermus thermophilus L-malate + NAD+
-
r
oxaloacetate + NADH
-
Escherichia coli L-malate + NAD+
-
r
oxaloacetate + NADH
-
Geobacillus stearothermophilus L-malate + NAD+
-
r
oxaloacetate + NADH
-
Methanothermus fervidus L-malate + NAD+
-
r
oxaloacetate + NADH
-
Streptosporangium roseum L-malate + NAD+
-
r
oxaloacetate + NADH
-
Citrullus lanatus L-malate + NAD+
-
r
oxaloacetate + NADH
-
Chlorobaculum tepidum L-malate + NAD+
-
r
oxaloacetate + NADH
-
Syntrophobacter fumaroxidans L-malate + NAD+
-
r
oxaloacetate + NADH
-
Planomonospora venezuelensis L-malate + NAD+
-
r
oxaloacetate + NADH
-
Streptomyces atratus L-malate + NAD+
-
r
oxaloacetate + NADH
-
Phenylobacterium immobile L-malate + NAD+
-
r
oxaloacetate + NADH
-
Prosthecochloris vibrioformis L-malate + NAD+
-
r
oxaloacetate + NADH
-
Heliomicrobium gestii L-malate + NAD+
-
r
oxaloacetate + NADH
-
Syntrophobacter fumaroxidans MPOB L-malate + NAD+
-
r

Subunits

Subunits Comment Organism
dimer
-
Thermus thermophilus
dimer 2 * 35000, SDS-PAGE Syntrophobacter fumaroxidans

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
-
Syntrophobacter fumaroxidans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
reduction of oxaloacetate Syntrophobacter fumaroxidans
8.5
-
-
Syntrophobacter fumaroxidans
9
-
oxidation of L-malate Syntrophobacter fumaroxidans

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Syntrophobacter fumaroxidans
NADP+ low activity with Syntrophobacter fumaroxidans