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Literature summary for 1.1.1.37 extracted from

  • Emyanitoff, R.G.; Kelly, P.J.
    Kinetic characterization of Mitochondrial malate dehydrogenase from Dictyostelium discoideum (1982), J. Gen. Microbiol., 128, 1767-1771.
    View publication on PubMed
Search for more literature for 1.1.1.37

Inhibitors

Inhibitors Comment Organism Structure
Hydroxymalonate
-
 Dictyostelium discoideum
Hydroxymalonate
-
 Sus scrofa
thyroxine
-
 Dictyostelium discoideum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
 NADH whole cell MDH Dictyostelium discoideum
0.04
-
 NADH mitochondrial MDH Dictyostelium discoideum
0.1
-
 NAD+ mitochondrial MDH Dictyostelium discoideum
0.14
-
 NAD+
-
 Dictyostelium discoideum
0.17
-
 oxaloacetate
-
 Dictyostelium discoideum
0.27
-
 oxaloacetate mitochondrial MDH Dictyostelium discoideum
1.33
-
 L-malate mitochondrial MDH Dictyostelium discoideum
5
-
 L-malate
-
 Dictyostelium discoideum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Sus scrofa 5737
-
cytoplasm
-
 Saccharomyces cerevisiae 5737
-
cytoplasm
-
 Bos taurus 5737
-
cytoplasm
-
 Dictyostelium discoideum 5737
-
cytoplasm
-
 Physarum polycephalum 5737
-
cytoplasm
-
 Gallus sp. 5737
-
mitochondrion
-
 Sus scrofa 5739
-
mitochondrion
-
 Saccharomyces cerevisiae 5739
-
mitochondrion
-
 Bos taurus 5739
-
mitochondrion
-
 Dictyostelium discoideum 5739
-
mitochondrion
-
 Physarum polycephalum 5739
-
mitochondrion
-
 Gallus sp. 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
-
 Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
malate + NAD+ Sus scrofa
-
 oxaloacetate + NADH + H+
-
 r
malate + NAD+ Saccharomyces cerevisiae
-
 oxaloacetate + NADH + H+
-
 r
malate + NAD+ Bos taurus
-
 oxaloacetate + NADH + H+
-
 r
malate + NAD+ Dictyostelium discoideum
-
 oxaloacetate + NADH + H+
-
 r
malate + NAD+ Schizosaccharomyces pombe
-
 oxaloacetate + NADH + H+
-
 r
malate + NAD+ Physarum polycephalum
-
 oxaloacetate + NADH + H+
-
 r
malate + NAD+ Gallus sp.
-
 oxaloacetate + NADH + H+
-
 r
malate + NAD+ Dictyostelium discoideum NC-4 / ATCC 24697
-
 oxaloacetate + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Dictyostelium discoideum
-
-
-
Dictyostelium discoideum NC-4 / ATCC 24697
-
-
-
Gallus sp.
-
 chicken
-
Physarum polycephalum
-
-
-
Saccharomyces cerevisiae
-
 yeast
-
Schizosaccharomyces pombe
-
-
-
Sus scrofa
-
 pig
-

Purification (Commentary)

Purification (Comment) Organism
-
 Dictyostelium discoideum

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Sus scrofa
-
heart
-
 Bos taurus
-
heart
-
 Gallus sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
550
-
-
 Dictyostelium discoideum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
 Sus scrofa oxaloacetate + NADH + H+
-
 r
(S)-malate + NAD+
-
 Saccharomyces cerevisiae oxaloacetate + NADH + H+
-
 r
(S)-malate + NAD+
-
 Bos taurus oxaloacetate + NADH + H+
-
 r
(S)-malate + NAD+
-
 Dictyostelium discoideum oxaloacetate + NADH + H+
-
 r
(S)-malate + NAD+
-
 Schizosaccharomyces pombe oxaloacetate + NADH + H+
-
 r
(S)-malate + NAD+
-
 Physarum polycephalum oxaloacetate + NADH + H+
-
 r
(S)-malate + NAD+
-
 Gallus sp. oxaloacetate + NADH + H+
-
 r
(S)-malate + NAD+
-
 Dictyostelium discoideum NC-4 / ATCC 24697 oxaloacetate + NADH + H+
-
 r
malate + NAD+
-
 Sus scrofa oxaloacetate + NADH + H+
-
 r
malate + NAD+
-
 Saccharomyces cerevisiae oxaloacetate + NADH + H+
-
 r
malate + NAD+
-
 Bos taurus oxaloacetate + NADH + H+
-
 r
malate + NAD+
-
 Dictyostelium discoideum oxaloacetate + NADH + H+
-
 r
malate + NAD+
-
 Schizosaccharomyces pombe oxaloacetate + NADH + H+
-
 r
malate + NAD+
-
 Physarum polycephalum oxaloacetate + NADH + H+
-
 r
malate + NAD+
-
 Gallus sp. oxaloacetate + NADH + H+
-
 r
malate + NAD+
-
 Dictyostelium discoideum NC-4 / ATCC 24697 oxaloacetate + NADH + H+
-
 r
oxaloacetate + NADH
-
 Sus scrofa L-malate + NAD+
-
 r
oxaloacetate + NADH
-
 Saccharomyces cerevisiae L-malate + NAD+
-
 r
oxaloacetate + NADH
-
 Bos taurus L-malate + NAD+
-
 r
oxaloacetate + NADH
-
 Dictyostelium discoideum L-malate + NAD+
-
 r
oxaloacetate + NADH
-
 Schizosaccharomyces pombe L-malate + NAD+
-
 r
oxaloacetate + NADH
-
 Physarum polycephalum L-malate + NAD+
-
 r
oxaloacetate + NADH
-
 Gallus sp. L-malate + NAD+
-
 r
oxaloacetate + NADH
-
 Dictyostelium discoideum NC-4 / ATCC 24697 L-malate + NAD+
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.3 9.5 both isoenzymes Dictyostelium discoideum