Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-diphospho-5'-adenosine | inhibits competitively with respect to glucose 6-phosphate and noncompetitively with respect to NAD+ or NADP+. 0.85 mol of pyridoxal 5'-diphospho-5'-adenosine is required for complete inactivation. Lys21 and Lys343 are the sites of pyridoxal 5'-diphospho-5'-adenosine interaction. Both glucose 6-phosphate and NAD+ protect both lysyl residues against this covalent modification | Leuconostoc mesenteroides | |
pyridoxal 5'-phosphate | modifies Lys21 and probably Lys343 | Leuconostoc mesenteroides |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + NAD+ | Leuconostoc mesenteroides | - |
6-phospho-D-glucono-1,5-lactone + NADH + H+ | - |
? | |
D-glucose 6-phosphate + NADP+ | Leuconostoc mesenteroides | - |
6-phospho-D-glucono-1,5-lactone + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leuconostoc mesenteroides | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + NAD+ | - |
Leuconostoc mesenteroides | 6-phospho-D-glucono-1,5-lactone + NADH + H+ | - |
? | |
D-glucose 6-phosphate + NADP+ | - |
Leuconostoc mesenteroides | 6-phospho-D-glucono-1,5-lactone + NADPH + H+ | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Leuconostoc mesenteroides |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Leuconostoc mesenteroides |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.034 | - |
pyridoxal 5'-diphospho-5'-adenosine | 25°C, pH 7.8, NAD+-linked reaction | Leuconostoc mesenteroides | |
0.04 | - |
pyridoxal 5'-diphospho-5'-adenosine | 25°C, pH 7.8, NADP+-linked reaction | Leuconostoc mesenteroides |