Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.36 extracted from

  • Saito, T.; Fukui, T.; Ikeda, F.; Tanaka, Y.; Tomita, K.
    An NADP-linked acetoacetyl CoA reductase from Zoogloea ramigera (1977), Arch. Microbiol., 114, 211-217.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetoacetyl-CoA above 0.01 mM Zoogloea ramigera

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0083
-
acetoacetyl-CoA cofactor NADPH Zoogloea ramigera
0.02 0.021 NADPH cosubstrate acetoacetyl-CoA Zoogloea ramigera

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetoacetyl-CoA + NADH + H+ Zoogloea ramigera low activity L-3-hydroxybutyryl-CoA + NAD+
-
r
acetoacetyl-CoA + NADPH + H+ Zoogloea ramigera high activity D-3-hydroxybutyryl-CoA + NADP+
-
r
acetoacetyl-CoA + NADPH + H+ Zoogloea ramigera PHB synthesis D-3-hydroxybutyryl-CoA + NADP+
-
r
acetoacetyl-CoA + NADPH + H+ Azotobacter beijerinckii PHB synthesis D-3-hydroxybutyryl-CoA + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Azotobacter beijerinckii
-
-
-
Zoogloea ramigera
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate fractionation, hydroxylapatite, Sephadex G-200 chromatography Zoogloea ramigera

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.7
-
NADPH-linked Zoogloea ramigera

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetoacetyl-CoA + NADH + H+ low activity Zoogloea ramigera L-3-hydroxybutyryl-CoA + NAD+
-
r
acetoacetyl-CoA + NADPH + H+
-
Zoogloea ramigera (3R)-3-hydroxybutyryl-CoA + NADP+
-
r
acetoacetyl-CoA + NADPH + H+
-
Azotobacter beijerinckii (3R)-3-hydroxybutyryl-CoA + NADP+
-
r
acetoacetyl-CoA + NADPH + H+ high activity Zoogloea ramigera D-3-hydroxybutyryl-CoA + NADP+
-
r
acetoacetyl-CoA + NADPH + H+ PHB synthesis Zoogloea ramigera D-3-hydroxybutyryl-CoA + NADP+
-
r
acetoacetyl-CoA + NADPH + H+ PHB synthesis Azotobacter beijerinckii D-3-hydroxybutyryl-CoA + NADP+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
-
Zoogloea ramigera

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.1
-
reduction of acetoacetyl-CoA Zoogloea ramigera

Cofactor

Cofactor Comment Organism Structure
NADH
-
Zoogloea ramigera
NADH
-
Azotobacter beijerinckii
NADP+
-
Zoogloea ramigera
NADP+
-
Azotobacter beijerinckii
NADPH
-
Zoogloea ramigera
NADPH
-
Azotobacter beijerinckii