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Literature summary for 1.1.1.35 extracted from

  • Beaudoin, F.; Wu, X.; Li, F.; Haslam, R.P.; Markham, J.E.; Zheng, H.; Napier, J.A.; Kunst, L.
    Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase (2009), Plant Physiol., 150, 1174-1191.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in yeast ybr159DELTA mutant Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information loss of KCR1 function results in embryo lethality, which cannot be rescued by KCR2 expression using the KCR1 promoter. Disruption of the KCR2 gene has no obvious phenotypic effect Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
RNAi suppressed KCR activity results in a reduction of cuticular wax load and affects very-long-chain fatty acid composition of sphingolipids, seed triacylglycerols, and root glycerolipids Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum KCR1 and KCR2 Arabidopsis thaliana 5783
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
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-
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Source Tissue

Source Tissue Comment Organism Textmining
embryo KCR1 and KCR2 transcripts Arabidopsis thaliana
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flower KCR1 and KCR2 transcripts Arabidopsis thaliana
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leaf KCR1 and KCR2 transcripts Arabidopsis thaliana
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additional information KCR1 and KCR2 transcripts in inflorescence stems Arabidopsis thaliana
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root only KCR1 transcript Arabidopsis thaliana
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silique KCR1 and KCR2 transcripts Arabidopsis thaliana
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information KCR1 can complement the yeast ybr159DELTA mutant, KCR proteins are divergent, only KCR1 can restore heterologous elongase activity, thus only KCR1 is a functional KCR isoform involved in microsomal fatty acid elongation Arabidopsis thaliana ?
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?

Synonyms

Synonyms Comment Organism
beta-ketoacyl reductase
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Arabidopsis thaliana
beta-ketoacyl-coenzyme A reductase
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Arabidopsis thaliana
KCR1
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Arabidopsis thaliana
KCR2
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Arabidopsis thaliana