Cloned (Comment) | Organism |
---|---|
C-terminal hexameric histidine tag, expressed in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
50 mM N(2-acetamido)-2-iminodiacetic acid, pH 6.5, polyethylene glycol 4000, 5 mM NAD+ hanging drop, crystals within 3 to 5 days at 18°C, enzyme structure is compromised of two domains, a NAD+-binding domain and a helical C-terminal domain | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0138 | - |
acetoacetyl-CoA | pH 8.0 | Homo sapiens | |
0.0187 | - |
acetoacetyl-CoA | pH 7.0 | Homo sapiens | |
0.0345 | - |
acetoacetyl-CoA | pH 5.0 | Homo sapiens | |
0.045 | - |
acetoacetyl-CoA | pH 6.0 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34000 | - |
2 * 34000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxybutyryl-CoA + NAD+ | Homo sapiens | - |
acetoacetyl-CoA + NADH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1200 | - |
His-tagged recombinant enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxybutyryl-CoA + NAD+ | - |
Homo sapiens | acetoacetyl-CoA + NADH | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 34000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
short chain L-3-hydroxyacyl-CoA dehydrogenase | displays optimal activity using 6-carbon substrates | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
113 | - |
acetoacetyl-CoA | pH 8.0 | Homo sapiens | |
155 | - |
acetoacetyl-CoA | pH 5.0 | Homo sapiens | |
246 | - |
acetoacetyl-CoA | pH 6.0 | Homo sapiens | |
252 | - |
acetoacetyl-CoA | pH 7.0 | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |