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Literature summary for 1.1.1.34 extracted from

  • Andrade-Pavon, D.; Ortiz-Alvarez, J.; Sanchez-Sandoval, E.; Tamariz, J.; Hernandez-Rodriguez, C.; Ibarra, J.A.; Villa-Tanaca, L.
    Inhibition of recombinant enzyme 3-hydroxy-3-methylglutaryl-CoA reductase from Candida glabrata by alpha-asarone-based synthetic compounds as antifungal agents (2019), J. Biotechnol., 292, 64-67 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-asarone 9.4% inhibition at 0.1 mM [Candida] glabrata
methyl (2-methoxy-5-nitro-4-propylphenoxy)acetate 96.8% inhibition at 0.1 mM [Candida] glabrata
methyl (4-ethyl-2-nitrophenoxy)acetate 84.9% inhibition at 0.1 mM [Candida] glabrata
simvastatin
-
[Candida] glabrata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ [Candida] glabrata
-
(R)-mevalonate + CoA + 2 NADP+
-
?
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ [Candida] glabrata CBS138
-
(R)-mevalonate + CoA + 2 NADP+
-
?

Organism

Organism UniProt Comment Textmining
[Candida] glabrata
-
-
-
[Candida] glabrata CBS138
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
[Candida] glabrata (R)-mevalonate + CoA + 2 NADP+
-
?
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
[Candida] glabrata CBS138 (R)-mevalonate + CoA + 2 NADP+
-
?

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl-CoA reductase
-
[Candida] glabrata
HMGR
-
[Candida] glabrata

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.02877
-
at pH 8.0 and 37°C [Candida] glabrata methyl (4-ethyl-2-nitrophenoxy)acetate
0.04265
-
at pH 8.0 and 37°C [Candida] glabrata methyl (2-methoxy-5-nitro-4-propylphenoxy)acetate