Protein Variants | Comment | Organism |
---|---|---|
S872D | the mutation reduces the catalytic activity of the enzyme similarly to that of the phosphorylated enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-mevalonate + CoA + 2 NADP+ | Homo sapiens | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
r | |
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Homo sapiens | - |
(R)-mevalonate + CoA + 2 NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04035 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme is phosphorylated at Ser872 by AMP-activated protein kinase and reversibly dephosphorylated by phosphatase 2A | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-mevalonate + CoA + 2 NADP+ | - |
Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
r | |
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Homo sapiens | (R)-mevalonate + CoA + 2 NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
homotetramer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxy-3-methylglutaryl coenzyme A reductase | - |
Homo sapiens |
HMG-CoA reductase | - |
Homo sapiens |
HMGR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |