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Literature summary for 1.1.1.34 extracted from

  • Zhao, Q.; Li, R.; Chen, X.; Yang, Q.; Li, J.
    Cloning and characterization of the gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase from Fritillaria cirrhosa D. Don (2018), Braz. Arch. Biol. Technol., 61, e181170788.
No PubMed abstract available
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Cloned(Commentary)

Cloned (Comment) Organism
a truncated version of the protein lacking the N-terminal 249-bp GC rich area is expressed in Escherichia coli BL21(DE3) cells Fritillaria cirrhosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Fritillaria cirrhosa
-
 (R)-mevalonate + CoA + 2 NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Fritillaria cirrhosa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bulb highest expression in mature bulbs Fritillaria cirrhosa
-
leaf lowest expression Fritillaria cirrhosa
-
root
-
 Fritillaria cirrhosa
-
stem
-
 Fritillaria cirrhosa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Fritillaria cirrhosa (R)-mevalonate + CoA + 2 NADP+
-
 ?

Subunits

Subunits Comment Organism
? x * 59200, calculated from amino acid sequence Fritillaria cirrhosa
? x * 75000, GST-tagged recombinant enzyme, SDS-PAGE Fritillaria cirrhosa

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl-coenzyme A reductase
-
 Fritillaria cirrhosa
HMG-CoA reductase
-
 Fritillaria cirrhosa
HMGR
-
 Fritillaria cirrhosa

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Fritillaria cirrhosa

pI Value

Organism Comment pI Value Maximum pI Value
Fritillaria cirrhosa calculated from amino acid sequence
-
 7.5