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Literature summary for 1.1.1.34 extracted from

  • Aquil, S.; Husaini, A.M.; Abdin, M.Z.; Rather, G.M.
    Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants (2009), Planta Med., 75, 1453-1458.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information leaf tissue of Artemisia annua transgenic lines possess significantly higher HMGR activity compared with wild-type controls, and this activity is associated exclusively with microsomal membranes and with higher artemisinin content (increase of up to 22.5% artemisin in content compared with wild-type control Artemisia annua plants) Catharanthus roseus

Application

Application Comment Organism
drug development overexpression of HMGR appears promising for obtaining a constant high production of artemisinin, an effective drug against malaria for which no resistant strains of Plasmodium falciparum have been reported Catharanthus roseus

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of the HMGR gene in transgenic Artemisia annua plants using Agrobacterium-mediated gene transfer technology Catharanthus roseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH Catharanthus roseus
-
mevalonate + CoA + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Catharanthus roseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Catharanthus roseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADPH
-
Catharanthus roseus mevalonate + CoA + NADP+
-
?

Synonyms

Synonyms Comment Organism
HMG-CoA reductase
-
Catharanthus roseus
HMGR
-
Catharanthus roseus