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Literature summary for 1.1.1.34 extracted from

  • Shearer, A.G.; Hampton, R.Y.
    Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase (2004), J. Biol. Chem., 279, 188-196.
    View publication on PubMed
Search for more literature for 1.1.1.34

Cloned(Commentary)

Cloned (Comment) Organism
expression of c-myc-tagged enzyme from plasmid in yeast, expression as GFP-fusion protein Saccharomyces cerevisiae

General Stability

General Stability Organism
glycerol strongly stabilizes the enzyme, stabilization against endoplasmic reticulum-associated degradation Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
cycloheximide
-
 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Saccharomyces cerevisiae 5783
-
membrane
-
 Saccharomyces cerevisiae 16020
-
microsome
-
 Saccharomyces cerevisiae
-
-
additional information enzyme undergoes endoplasmic reticulum-associated degradation which is physiologically regulated by sterol pathway signals Saccharomyces cerevisiae
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae enzyme undergoes endoplasmic reticulum-associated degradation which is physiologically regulated by sterol pathway signals, determination of structural features leading to modification and degradation by the quality control system of the endoplasmic reticulum, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially, preparation of microsomes and solubilization by trypsin Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme undergoes endoplasmic reticulum-associated degradation which is physiologically regulated by sterol pathway signals, determination of structural features leading to modification and degradation by the quality control system of the endoplasmic reticulum, overview Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl CoA reductase
-
 Saccharomyces cerevisiae
Hmg2p
-
 Saccharomyces cerevisiae