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Literature summary for 1.1.1.331 extracted from

  • Morimoto, K.; Satake, H.
    Seasonal alteration in amounts of lignans and their glucosides and gene expression of the relevant biosynthetic enzymes in the Forsythia suspense leaf (2013), Biol. Pharm. Bull., 36, 1519-1523 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(-)-secoisolariciresinol + 2 NAD+ Forsythia x intermedia
-
(-)-matairesinol + 2 NADH + 2 H+
-
?

Organism

Organism UniProt Comment Textmining
Forsythia x intermedia Q94KL7 Forsythia suspensa x Forsythia viridissima
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf seasonal alteration in amounts of major lignans, such as pinoresinol, matairesinol, and arctigenin, analysis of gene expression profile of secoisolariciresinol dehydrogenase (SIRD) and other related enzymes in the leaves of Forsythia suspense from April to November. The SIRD expression is prominent from April to May, not detected in June to July, and then increases again from September to November. All of the lignans in the leaf continuously increase from April to June, reach the maximal level in June, and then decrease Forsythia x intermedia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(-)-secoisolariciresinol + 2 NAD+
-
Forsythia x intermedia (-)-matairesinol + 2 NADH + 2 H+
-
?

Synonyms

Synonyms Comment Organism
SirD
-
Forsythia x intermedia

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Forsythia x intermedia

General Information

General Information Comment Organism
metabolism the enzyme is involved in the lignan biosynthetic pathways in Forsythia, overview Forsythia x intermedia
physiological function the enzyme SIRD is involved in the biosynthesis of lignan matairesinol in Forsythia. The leaves show seasonal alteration in amounts of major lignans, such as pinoresinol, matairesinol, and arctigenin, gene expression profile of secoisolariciresinol dehydrogenase (SIRD) and other related enzymes in the leaves of Forsythia suspense from April to November: all of the lignans in the leaf continuously increase from April to June, reach the maximal level in June, and then decrease Forsythia x intermedia