Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P38286 | - |
- |
Synonyms | Comment | Organism |
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ybr159 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
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physiological function | a Ybr159 gene disruption mutant shows reduced very long-chain fatty acid synthesis, accumulation of high levels of dihydrosphingosine and phytosphingosine, and accumulation of medium-chain ceramides. Mutant is deficient in the reduction of the 3-ketoacyl intermediates of fatty acid elongation. The mutant also displays reduced dehydration of the 3-OH acyl intermediates of fatty acid elongation, suggesting that its gene is required for the stability or function of the dehydratase activity of the elongase system. The enzyme protein co-localizes and co-immunoprecipitates with other elongating enzymes, Elo3p and Tsc13p. Whereas very long-chain fatty acid synthesis is essential for viability, the deletion mutant cells are viable albeit very slowly growing and do synthesize some very long-chain fatty acids. A ybr159ayr1 double mutant is inviable, suggesting that Ayr1p is responsible for the residual 3-ketoreductase activity | Saccharomyces cerevisiae |