Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.315 extracted from

  • Xue, Y.; Sato, S.; Razafsky, D.; Sahu, B.; Shen, S.Q.; Potter, C.; Sandell, L.L.; Corbo, J.C.; Palczewski, K.; Maeda, A.; Hodzic, D.; Kefalov, V.J.
    The role of retinol dehydrogenase 10 in the cone visual cycle (2017), Sci. Rep., 7, 2390 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.315

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye
-
 Mus musculus
-
retina
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
11-cis-RDH
-
 Mus musculus

General Information

General Information Comment Organism
malfunction RDH10 is not required for the function of the retina visual cycle. Transgenic mice expressing RDH10 ectopically in rod cells show, that rod dark adaptation is unaffected by the expression of RDH10 and transgenic rods were unable to use cis-retinol for pigment regeneration Mus musculus
physiological function cone-specific 11-cis-RDH is likely to be important in regulating access to the retina visual cycle. Retinol dehydrogenase 10, RDH10 (UniProt ID Q8VCH7), is not the dominant retina 11-cis-RDH, it catalyzes the all-transretinol convertion, cf. EC 1.1.1.300 Mus musculus