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Literature summary for 1.1.1.315 extracted from
- Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal G protein-coupled receptor opsin (2001), J. Biol. Chem., 276, 21098-21104.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Bos taurus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32000 | - |
x * 32000, SDS-PAGE | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+ | Bos taurus | - |
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+ | - |
? |  |
| 11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+ | Bos taurus | - |
11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+ | - |
? | |
| additional information | Bos taurus | cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| enzyme copurifies with retinal G protein coupled receptor from microsomes | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| retina | - |
Bos taurus | - |
| retinal pigment epithelium | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+ | - |
Bos taurus | 11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+ | - |
? | |
| 11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+ | - |
Bos taurus | 11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+ | - |
? | |
| additional information | cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR | Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 32000, SDS-PAGE | Bos taurus |
| More | enzyme copurifies with retinal G protein coupled receptor from microsomes | Bos taurus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cRDH | - |
Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | NAD+ is preferred over NADP+ | Bos taurus | |
| NADP+ | NAD+ is preferred over NADP+ | Bos taurus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | cRDH is involved in the processing of 11-cis-retinal after irradiation of retinal G protein-coupled receptor RGR opsin and plays a role in the visual cycle | Bos taurus |
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Release 2023.1 (January 2023)
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