Literature summary for 1.1.1.315 extracted from

Simon, A.; Hellman, U.; Wernstedt, C.; Eriksson, U.
The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases (1995), J. Biol. Chem., 270, 1107-1112.

Search for more literature for 1.1.1.315

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Cos-1 cells	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	associated to membrane, and ssequence displays several potential membrane-spanning segments	Bos taurus	16020	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
32000	-	x * 32000, SDS-PAGE	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	Q27979	sequence similarities to short chain alcohol dehydrogenases	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	N-terminal 18 amino acids of sequence have the characteristics of a classigal signal sequence	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
retinal pigment epithelium	specific expression	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
11-cis-retinol + NAD+	-	Bos taurus	11-cis-retinal + NADH + H+	-	?

Subunits

Subunits	Comment	Organism
?	x * 32000, SDS-PAGE	Bos taurus
More	enzyme associates with p63, an abundant membrane protein in retinal pigment epithelium	Bos taurus

Cofactor

Cofactor	Comment	Organism	Structure
additional information	no cofactor: NADP+	Bos taurus
NAD+	-	Bos taurus

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Release 2023.1 (January 2023)