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Literature summary for 1.1.1.315 extracted from
- Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE (2002), Invest. Ophthalmol. Vis. Sci., 43, 3365-3372.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
- |
Bos taurus |
| RDH10 is expressed in COS cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Bos taurus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38087 | - |
x * 38087, calculated from sequence | Homo sapiens |
| 38090 | - |
calculated from sequence | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | Q8HZT6 | - |
- |
| Homo sapiens | Q8IZV5 | - |
- |
| Mus musculus | Q8VCH7 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | low activity | Bos taurus | - |
| kidney | low activity | Bos taurus | - |
| liver | low activity | Bos taurus | - |
| lung | low activity | Bos taurus | - |
| pancreas | low activity | Bos taurus | - |
| retinal pigment epithelium | - |
Homo sapiens | - |
| retinal pigment epithelium | - |
Mus musculus | - |
| retinal pigment epithelium | high activity | Bos taurus | - |
| skeletal muscle | low activity | Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| all-trans-retinol + NAD+ | the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 | Homo sapiens | all-trans-retinal + NADH + H+ | - |
r |  |
| all-trans-retinol + NAD+ | the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 | Mus musculus | all-trans-retinal + NADH + H+ | - |
r | |
| all-trans-retinol + NAD+ | the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 | Bos taurus | all-trans-retinal + NADH + H+ | - |
r | |
| all-trans-retinol + NADP+ | the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 | Homo sapiens | all-trans-retinal + NADPH + H+ | - |
r | |
| all-trans-retinol + NADP+ | the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 | Mus musculus | all-trans-retinal + NADPH + H+ | - |
r | |
| all-trans-retinol + NADP+ | the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 | Bos taurus | all-trans-retinal + NADPH + H+ | - |
r | |
| additional information | RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10 | Homo sapiens | ? | - |
? | |
| additional information | RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10 | Mus musculus | ? | - |
? | |
| additional information | RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10 | Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 38087, calculated from sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| atRDH | - |
Homo sapiens |
| atRDH | - |
Mus musculus |
| atRDH | - |
Bos taurus |
| RDH10 | - |
Homo sapiens |
| RDH10 | - |
Mus musculus |
| RDH10 | - |
Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor | Mus musculus | |
| NAD+ | the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor | Bos taurus | |
| NAD+ | the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP+ as the cofactor | Homo sapiens | |
| NADH | - |
Homo sapiens | |
| NADH | - |
Mus musculus | |
| NADH | - |
Bos taurus | |
| NADP+ | the addition of NADP+ resulted in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP+ as the cofactor | Homo sapiens | |
| NADP+ | the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor | Mus musculus | |
| NADP+ | the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor | Bos taurus | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Mus musculus | |
| NADPH | - |
Bos taurus | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | calculated from sequence | - |
7.4 |
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