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Literature summary for 1.1.1.300 extracted from

  • Suzuki, H.; Ozaki, Y.; Gen, K.; Kazeto, Y.
    Japanese eel retinol dehydrogenases 11/12-like are 17-ketosteroid reductases involved in sex steroid synthesis (2021), Gen. Comp. Endocrinol., 305, 113685 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene rdh11, cloning of Rdh11/12-like 1-3 variants on the basis of template coding region of human rdh11 cDNA, DNA and amino acid determination and analysis, genetic structure, and quantitative RT-PCR expression analysis, sequence comparisons, recombinant expression of Rdh11/12-like 1 in HEK-293T cells resulting in no significant activity in conversion of T to A4 or E2 to E1 compared to the mock control Anguilla japonica

Organism

Organism UniProt Comment Textmining
Anguilla japonica
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Anguilla japonica
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eye
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germ cell
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hypophysis
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Leydig cell
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additional information quantitative RT-PCR expression analysis, expression pattern in different tissues. The pituitary and parts of brain and testis are the predominant sources of rdh11/12-like 1 transcript, while rdh11/12-like 2 mRNA is mostly detected in pituitary, parts of the brain, eye, and testis. Expression of rdh11/12-like 3, on the other hand, is ubiquitous across the tissues analyzed Anguilla japonica
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Sertoli cell
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testis Leydig cells, Sertoli cells, and germ cells: rdh11/12-like 1 and rdh11/12-like 3 transcripts are detected in all three fractions with no significant differences in expression level among the different fractions. In contrast, rdh11/12-like 2 mRNA is detected only in the germ cell fraction Anguilla japonica
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Synonyms

Synonyms Comment Organism
More see also EC 1.1.1.51 Anguilla japonica
RDH11
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Anguilla japonica
Rdh11/12-like 1
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Rdh11/12-like 2
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Rdh11/12-like 3
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Anguilla japonica
retinol dehydrogenases 11-like
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Anguilla japonica

Cofactor

Cofactor Comment Organism Structure
NADP+
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Anguilla japonica
NADPH
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Anguilla japonica

Expression

Organism Comment Expression
Anguilla japonica recombinant equine gonadotropins (reFSH and reLH) and 11-oxotestosterone (11KT) have no effects on the expression of rdh11/12-like transcripts in the testis additional information

General Information

General Information Comment Organism
evolution all three proteins (Rdh11/12-like 1-3) include conserved signatures of the SDR family, such as cofactor binding (TGXXXGXG), the catalytic mechanism (YXXXK), and the structural integrity (NVG or NAG) patterns. Japanese eel Rdh11/12-like 1 clusters with piscine Rdh11 and Rdh12, however the cluster is formed outside that of mammalian Rdh11 and Rdh12. In contrast, Rdh11/12-like 2 and Rdh11/12-like 3 form a clade with putative European eel Rdh11s and Rdh12s outside that of mammalian and piscine Rdh11/Rdh12 Anguilla japonica
physiological function Japanese eel retinol dehydrogenases 11/12-like 1-3 (Rdh11/12-like 1-3) are 17-oxosteroid reductases (EC 1.1.1.51) involved in sex steroid synthesis. Catalysis of the conversion of A4 to T and E1 to E2 is performed by recombinant Rdh11/12-like 1 Anguilla japonica