BRENDA - Enzyme Database show
show all sequences of 1.1.1.300

Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo

Kasus-Jacobi, A.; Ou, J.; Birch, D.G.; Locke, K.G.; Shelton, J.M.; Richardson, J.A.; Murphy, A.J.; Valenzuela, D.M.; Yancopoulos, G.D.; Edwards, A.O.; J. Biol. Chem. 280, 20413-20420 (2005)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
cloned as a gene regulated by the transcription factor sterol regulatory element binding proteins and previously named SCALD for short chain aldehyde reductase
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
photoreceptor outer segment
rod
Homo sapiens
1750
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
O75911
-
-
Homo sapiens
Q8TC12
-
-
Homo sapiens
Q92781
-
-
Homo sapiens
Q96NR8
-
-
Homo sapiens
Q9HBH5
-
-
Homo sapiens
Q9NYR8
-
-
Mus musculus
Q9QYF1
mouse monoclonal anti-GRK1 (G-proteinassociated rhodopsin kinase-1)
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
eye
-
Homo sapiens
-
eye
-
Mus musculus
-
photoreceptor
-
Homo sapiens
-
photoreceptor
inner segment
Mus musculus
-
retinal pigment epithelium
;
Homo sapiens
-
retinal pigment epithelium
in vivo
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11-cis-retinal + NADPH + H+
-
669341
Homo sapiens
11-cis-retinol + NADP+
-
-
-
r
11-cis-retinal + NADPH + H+
The reverse reaction, oxidation of all-trans-retinol, is not catalyzed by mRDH11
669341
Mus musculus
11-cis-retinol + NADP+
-
-
-
ir
11-cis-retinol + NADP+
-
669341
Homo sapiens
11-cis-retinal + NADPH
-
-
-
?
all-trans-retinal + NADPH + H+
-
669341
Homo sapiens
all-trans-retinol + NADP+
-
-
-
r
all-trans-retinal + NADPH + H+
-
669341
Homo sapiens
all-tans-retinol + NADP+
-
-
-
r
all-trans-retinal + NADPH + H+
The reverse reaction, oxidation of all-trans-retinol, is not catalyzed by mRDH11
669341
Mus musculus
all-tans-retinol + NADP+
-
-
-
ir
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
;
Homo sapiens
NADP+
-
Mus musculus
NADPH
-
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
cloned as a gene regulated by the transcription factor sterol regulatory element binding proteins and previously named SCALD for short chain aldehyde reductase
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Homo sapiens
NADP+
-
Mus musculus
NADPH
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
photoreceptor outer segment
-
Homo sapiens
1750
-
photoreceptor outer segment
rod
Homo sapiens
1750
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
eye
-
Homo sapiens
-
eye
-
Mus musculus
-
photoreceptor
-
Homo sapiens
-
photoreceptor
inner segment
Mus musculus
-
retinal pigment epithelium
-
Homo sapiens
-
retinal pigment epithelium
in vivo
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11-cis-retinal + NADPH + H+
-
669341
Homo sapiens
11-cis-retinol + NADP+
-
-
-
r
11-cis-retinal + NADPH + H+
The reverse reaction, oxidation of all-trans-retinol, is not catalyzed by mRDH11
669341
Mus musculus
11-cis-retinol + NADP+
-
-
-
ir
11-cis-retinol + NADP+
-
669341
Homo sapiens
11-cis-retinal + NADPH
-
-
-
?
all-trans-retinal + NADPH + H+
-
669341
Homo sapiens
all-trans-retinol + NADP+
-
-
-
r
all-trans-retinal + NADPH + H+
-
669341
Homo sapiens
all-tans-retinol + NADP+
-
-
-
r
all-trans-retinal + NADPH + H+
The reverse reaction, oxidation of all-trans-retinol, is not catalyzed by mRDH11
669341
Mus musculus
all-tans-retinol + NADP+
-
-
-
ir
Other publictions for EC 1.1.1.300
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
739913
Hong
Alternative biotransformation ...
Bacillus cereus
Appl. Environ. Microbiol.
82
3940-3946
2016
-
-
1
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5
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5
-
-
-
-
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1
-
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1
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-
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10
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4
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5
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4
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1
4
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5
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5
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1
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10
-
4
-
-
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5
-
-
-
-
-
-
-
-
5
5
740378
Arregi
Retinol dehydrogenase-10 regul ...
Mus musculus
Endocrinology
157
4615-4631
2016
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2
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2
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-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
738670
Obrochta
Insulin regulates retinol dehy ...
Mus musculus
J. Biol. Chem.
290
7259-7268
2015
-
-
-
-
-
-
-
-
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1
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-
-
-
-
1
1
1
1
-
-
740107
Lhor
Structure of the N-terminal se ...
Homo sapiens
Biochim. Biophys. Acta
1848
878-885
2015
-
-
-
-
-
-
-
-
1
-
-
2
-
2
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2
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2
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2
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1
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2
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740415
Kummalue
Ribosomal protein L11- and ret ...
Homo sapiens
Exp. Hematol.
43
414-423.e1
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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2
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2
-
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-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
740899
Kolesnikov
Retinol dehydrogenase 8 and AT ...
Mus musculus
J. Physiol.
593
4923-4941
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738610
Adams
The retinaldehyde reductase ac ...
Homo sapiens, Mus musculus
J. Biol. Chem.
289
14868-14880
2014
-
-
2
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
3
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-
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-
-
-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
2
3
-
-
-
740719
Jiang
The retinol dehydrogenase Rdh1 ...
Mus musculus
J. Biol. Chem.
288
589-597
2013
-
-
1
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
-
-
1
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1
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1
1
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2
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722769
Chen
Reduction of all-trans-retinal ...
Mus musculus, Mus musculus C57BL/6 x 129/Sv
J. Biol. Chem.
287
24662-24670
2012
-
-
-
-
-
-
-
-
1
-
-
2
-
3
-
-
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-
-
2
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4
-
1
-
-
-
1
-
-
1
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-
-
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-
-
1
-
-
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-
-
-
-
1
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-
2
-
-
-
-
-
2
-
-
4
-
1
-
-
-
1
-
-
-
-
3
3
-
-
-
723236
Wang
Retinol dehydrogenase 13 prote ...
Mus musculus, Mus musculus C57BL/6 x 129/Sv
Mol. Vis.
18
1021-1030
2012
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
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1
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-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
722011
Lee
Evidence that proteosome inhib ...
Homo sapiens
Chem. Biol. Interact.
191
55-59
2011
-
-
1
-
2
-
-
-
1
-
-
2
-
1
-
-
1
-
-
1
-
-
2
-
1
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
2
-
-
-
-
-
1
-
-
2
-
-
-
1
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
712068
Marchette
Retinol dehydrogenase 12 detox ...
Mus musculus
Free Radic. Biol. Med.
48
16-25
2010
-
-
1
-
1
-
-
-
1
-
-
-
-
3
-
-
-
-
-
1
-
-
2
-
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-
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-
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2
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-
1
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2
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-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
712757
Haller
Molecular framework of steroid ...
Danio rerio, Homo sapiens
J. Mol. Biol.
399
255-267
2010
-
-
2
-
3
-
-
9
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
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-
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2
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3
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9
-
-
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-
-
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-
-
-
-
-
-
4
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
691107
Belyaeva
Identification and characteriz ...
Drosophila melanogaster
Biochim. Biophys. Acta
1790
1266-1273
2009
-
-
1
-
-
-
-
8
1
-
-
-
-
4
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
4
-
-
-
-
-
4
16
-
-
-
-
-
-
8
4
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685381
Lee
Effect of lipid peroxidation p ...
Homo sapiens
Biochim. Biophys. Acta
1782
421-425
2008
-
1
1
-
5
-
1
9
-
-
-
2
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
3
-
-
-
2
-
-
-
-
1
1
2
-
5
-
-
1
-
9
-
-
-
2
-
-
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-
-
-
-
-
3
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
686690
Belyaeva
Human retinol dehydrogenase 13 ...
Homo sapiens
FEBS J.
275
138-147
2008
-
-
1
-
-
-
1
4
1
-
-
1
-
2
1
-
1
-
-
6
-
-
3
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
1
-
4
1
-
-
1
-
1
-
1
-
6
-
-
3
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
687202
Kanan
Retinol dehydrogenases RDH11 a ...
Mus musculus
Invest. Ophthalmol. Vis. Sci.
49
1071-1078
2008
-
-
-
-
-
-
-
-
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2
-
5
-
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2
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2
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2
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4
-
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2
-
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-
-
-
-
691705
Pares
Medium- and short-chain dehydr ...
Homo sapiens, Mus musculus, Rattus norvegicus
Cell. Mol. Life Sci.
65
3936-3949
2008
-
-
-
-
-
-
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1
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3
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5
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-
-
-
6
-
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6
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1
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-
-
-
5
-
-
-
-
-
-
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-
-
-
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-
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-
-
699859
Yao
-
Catalytic reaction mechanism o ...
Homo sapiens
J. Theor. Comput. Chem.
7
565-578
2008
-
-
-
-
-
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1
-
-
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-
1
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1
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-
684939
Du
A 27.368 kDa retinal reductase ...
Oryctolagus cuniculus
Biochem. Cell Biol.
85
209-217
2007
-
-
-
-
-
-
-
-
1
-
4
1
-
4
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
4
1
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687139
Song
Expression of a novel alternat ...
Homo sapiens
Int. J. Cancer
120
1618-1626
2007
-
-
1
-
-
-
-
-
2
-
2
2
-
2
-
-
1
-
-
2
-
-
2
1
-
-
-
-
-
-
-
2
-
2
-
-
-
1
2
-
-
-
-
-
-
-
2
-
2
2
-
-
-
1
-
2
-
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
688677
Keller
RDH12, a retinol dehydrogenase ...
Homo sapiens, Mus musculus
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