Application | Comment | Organism |
---|---|---|
drug development | HSD is an interesting metabolic target in the search for drugs with selective antifungal action and low toxicity to the host | Paracoccidioides brasiliensis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | PbHSD inhibitor screening using the Zinc library, molecular dynamics simulations of PbHSD and ligand docking, electrostatic contacts between protein residues and the respective ligand atoms, overview. The selected ligands remain bound to the protein by a common mechanism throughout the simulation. Cytotoxicity evaluation in HeLa and Vero cells | Paracoccidioides brasiliensis | |
Zinc15967722 | MIC/MCF is 0.032 mg/ml | Paracoccidioides brasiliensis | |
Zinc20611644 | MIC/MCF is 0.128 mg/ml | Paracoccidioides brasiliensis | |
Zinc2123137 | MIC/MCF is 0.008 mg/ml | Paracoccidioides brasiliensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-homoserine + NAD+ | Paracoccidioides brasiliensis | - |
L-aspartate 4-semialdehyde + NADH + H+ | - |
r | |
L-homoserine + NAD+ | Paracoccidioides brasiliensis PB18 | - |
L-aspartate 4-semialdehyde + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Paracoccidioides brasiliensis | C1G1C3 | - |
- |
Paracoccidioides brasiliensis PB18 | C1G1C3 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-homoserine + NAD+ | - |
Paracoccidioides brasiliensis | L-aspartate 4-semialdehyde + NADH + H+ | - |
r | |
L-homoserine + NAD+ | - |
Paracoccidioides brasiliensis PB18 | L-aspartate 4-semialdehyde + NADH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
PbHSD | - |
Paracoccidioides brasiliensis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Paracoccidioides brasiliensis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Paracoccidioides brasiliensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Paracoccidioides brasiliensis | |
NADH | - |
Paracoccidioides brasiliensis |
General Information | Comment | Organism |
---|---|---|
physiological function | the homoserine dehydrogenase enzyme is essentially required for the biosynthesis of methionine, threonine, and isoleucine in fungi | Paracoccidioides brasiliensis |