Literature summary for 1.1.1.3 extracted from

Tsai, P.W.; Chien, C.Y.; Yeh, Y.C.; Tung, L.; Chen, H.F.; Chang, T.H.; Lan, C.Y.
Candida albicans Hom6 is a homoserine dehydrogenase involved in protein synthesis and cell adhesion (2017), J. Microbiol. Immunol. Infect., 50, 863-871.

Search for more literature for 1.1.1.3

Application

Application	Comment	Organism
drug development	the enzyme might be a good target for anti-fungal drug development	Candida albicans
additional information	HOM6 deletion reduces Candida albicans cell adhesion to polystyrene, which is a common plastic used in many medical devices	Candida albicans

Cloned(Commentary)

Cloned (Comment)	Organism
gene HOM6, DNA and amino acid sequence determination and analysis from the strain SC5314 genome, sequence comparison, reintegration of the gene encoding the wild-type enzyme into HOM6-deletion strains	Candida albicans

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of HOM6-deleted (HOM6/hom6DELT and hom6DELTA/hom6DELTA) and HOM6-reintegrated (hom6DELTA/hom6DELTA::HOM6 and hom6DELTA::HOM6/hom6DELTA::HOM6) strains	Candida albicans

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell wall	-	Candida albicans	5618	-
cytosol	-	Candida albicans	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-homoserine + NADP+	Candida albicans	-	L-aspartate 4-semialdehyde + NADPH + H+	-	r
L-homoserine + NADP+	Candida albicans SC5314 / ATCC MYA-2876	-	L-aspartate 4-semialdehyde + NADPH + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	Q5AIA2	-	-
Candida albicans SC5314 / ATCC MYA-2876	Q5AIA2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-homoserine + NADP+	-	Candida albicans	L-aspartate 4-semialdehyde + NADPH + H+	-	r
L-homoserine + NADP+	-	Candida albicans SC5314 / ATCC MYA-2876	L-aspartate 4-semialdehyde + NADPH + H+	-	r

Synonyms

Synonyms	Comment	Organism
Hom6	-	Candida albicans
orf19.2951	-	Candida albicans

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Candida albicans

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
9	-	assay at	Candida albicans

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Candida albicans
NADPH	-	Candida albicans

General Information

General Information	Comment	Organism
malfunction	HOM6 deletions cause translational arrest in cells grown under amino acid starvation conditions. HOM6 deletion reduces Candida albicans cell adhesion to polystyrene, which is a common plastic used in many medical devices. HOM6-homozygous mutants are hypersensitive to hygromycin B and cycloheximide as compared with wild-type, HOM6-heterozygous, and HOM6-reintegrated strains. HOM6 deletion affects translation and leads to the accumulation of free ribosomes	Candida albicans
metabolism	homoserine dehydrogenase activity and is involved in the biosynthesis of methionine and threonine	Candida albicans

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Release 2023.1 (January 2023)