Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases

DeLaBarre, B.; Thompson, P.R.; Wright, G.D.; Berghuis, A.M.; Nat. Struct. Biol. 7, 238-244 (2000)

Data extracted from this reference:

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

L-aspartate 4-semialdehyde + NAD(P)H

-

246396

Saccharomyces cerevisiae

L-homoserine + NAD(P)+

-

246396

Saccharomyces cerevisiae

-

Cofactor

Commentary

Organism

Structure

NADH

-

Saccharomyces cerevisiae

NADPH

-

Saccharomyces cerevisiae

Cofactor

Commentary

Organism

Structure

NADH

-

Saccharomyces cerevisiae

NADPH

-

Saccharomyces cerevisiae

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

L-aspartate 4-semialdehyde + NAD(P)H

-

246396

Saccharomyces cerevisiae

L-homoserine + NAD(P)+

-

246396

Saccharomyces cerevisiae

-

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Engineering

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Synonyms

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

KCat/KM [mM/s]

KCat/KM [mM/s] (protein specific)

740860

Tsai

Candida albicans Hom6 is a hom ...

Candida albicans, Candida albicans SC5314 / ATCC MYA-2876

J. Microbiol. Immunol. Infect.

50

863-871

2017

-

2

1

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1

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2

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2

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5

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1

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1

2

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1

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2

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-

2

-

1

-

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-

1

-

-

-

-

2

2

-

-

-

738802

Dong

Characterization of aspartate ...

Corynebacterium glutamicum, Corynebacterium glutamicum IWJ001

J. Ind. Microbiol. Biotechnol.

43

873-885

2016

-

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1

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2

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1

1

-

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739779

Chen

Rational design of allosteric ...

Corynebacterium glutamicum

ACS Synth. Biol.

4

126-131

2015

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1

1

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739791

Navratna

Structural basis for the catal ...

Staphylococcus aureus, Staphylococcus aureus COL

Acta Crystallogr. Sect. D

71

1216-1225

2015

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1

1

3

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2

1

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2

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2

2

1

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1

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3

3

-

-

-

739972

Tomonaga

-

Structural insight into activa ...

Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993 / JCM 10545 / NBRC 100140 / 7

Biochem. Biophys. Rep.

3

14-17

2015

1

-

1

1

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4

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2

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2

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1

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1

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1

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4

1

1

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1

-

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-

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1

1

-

-

-

741408

Hayashi

Crystal structures of a hypert ...

Pyrococcus horikoshii, Pyrococcus horikoshii ATCC 700860

Sci. Rep.

5

11674

2015

-

-

1

1

2

-

1

7

-

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2

2

-

2

-

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1

-

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4

1

1

1

-

2

5

1

-

1

5

1

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1

5

1

2

-

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1

1

7

-

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2

2

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-

1

-

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-

-

4

1

1

-

2

5

1

-

1

-

-

1

1

-

5

5

740548

Zhan

Exploring the molecular basis ...

Mycobacterium leprae, Mycobacterium leprae TN

Int. J. Mol. Sci.

15

1826-1841

2014

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-

-

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-

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7

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2

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5

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1

1

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1

7

5

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2

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2

1

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1

1

-

-

-

741465

Shen

-

Heterologous expression and ch ...

Corynebacterium pekinense, Corynebacterium pekinense AS1.299

Wei Sheng Wu Xue Bao

54

1178-1184

2014

-

-

1

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5

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2

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1

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739804

Navratna

Crystallization and preliminar ...

Staphylococcus aureus, Staphylococcus aureus COL

Acta Crystallogr. Sect. F

69

1216-1219

2013

-

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1

1

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2

2

-

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-

710978

Brautaset

Bacillus methanolicus pyruvate ...

Bacillus methanolicus, Bacillus methanolicus MGA3

Appl. Microbiol. Biotechnol.

87

951-964

2010

-

1

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1

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6

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1

1

1

2

-

-

712490

Schroeder

Threonine-insensitive homoseri ...

Glycine max

J. Biol. Chem.

285

827-834

2010

-

-

1

-

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-

2

23

-

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3

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5

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1

1

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1

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15

1

2

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12

-

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2

1

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3

2

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2

1

24

-

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3

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3

-

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1

-

15

1

-

-

-

12

-

-

-

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-

-

-

-

24

24

688167

Yilmaz

Targeted disruption of homoser ...

Streptomyces clavuligerus, Streptomyces clavuligerus NRRL 3585

J. Ind. Microbiol. Biotechnol.

35

1-7

2008

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1

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689647

Varisi

Lysine biosynthesis and nitrog ...

Chenopodium quinoa

Plant Physiol. Biochem.

46

11-18

2008

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2

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688822

Park

Characteristics of methionine ...

Corynebacterium glutamicum

Metab. Eng.

9

327-336

2007

-

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1

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1

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1

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3

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670165

Cahyanto

Regulation of aspartokinase, a ...

Lactobacillus plantarum

Microbiology

152

105-112

2006

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1

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662432

Curien

Identification of six novel al ...

Arabidopsis thaliana

J. Biol. Chem.

280

41178-41183

2005

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1

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654955

Ejim

New phenolic inhibitors of yea ...

Saccharomyces cerevisiae

Bioorg. Med. Chem.

12

3825-3830

2004

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1

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1

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13

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13

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642341

Paris

Mechanism of control of Arabid ...

Arabidopsis thaliana

J. Biol. Chem.

278

5361-5366

2003

-

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2

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657018

Rognes

Transcriptional and biochemica ...

Arabidopsis thaliana, Saccharomyces cerevisiae

Plant Mol. Biol.

51

281-294

2003

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1

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2

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1

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6

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642340

Paris

Overproduction, purification, ...

Arabidopsis thaliana

Protein Expr. Purif.

24

105-110

2002

-

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1

5

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654640

James

Production and characterizatio ...

Escherichia coli

Biochemistry

41

3720-3725

2002

-

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1

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4

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246401

Jacques

Homoserine dehydrogenase from ...

Saccharomyces cerevisiae

Biochim. Biophys. Acta

1544

42-54

2001

-

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4

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1

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3

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3

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246402

Jacques

Characterization of yeast homo ...

Saccharomyces cerevisiae

Biochim. Biophys. Acta

1544

28-41

2001

-

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1

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1

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3

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1

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246396

DeLaBarre

Crystal structures of homoseri ...

Saccharomyces cerevisiae

Nat. Struct. Biol.

7

238-244

2000

-

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-

1

-

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2

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1

1

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2

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2

1

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1

1

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246394

Morbach

-

Engineering the homoserine deh ...

Corynebacterium glutamicum

Appl. Microbiol. Biotechnol.

45

612-620

1996

-

-

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1

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2

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1

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1

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1

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1

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246395

Pavagi

Purification and characterizat ...

Spinacia oleracea

Biochem. Mol. Biol. Int.

36

649-658

1995

1

-

-

-

-

-

7

3

-

-

2

-

-

2

-

-

1

-

-

1

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2

1

-

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1

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7

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Kinetic and regulatory mechani ...

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Role of serine 352 in the allo ...

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Hama

Inhibition of homoserine dehyd ...

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J. Biochem.

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604-608

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Yumoto

Rapid purification and charact ...

Saccharomyces cerevisiae

Arch. Biochem. Biophys.

285

270-275

1991

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Yamaki

The mechanism of antifungal ac ...

Saccharomyces cerevisiae

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168

837-843

1990

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Angeles

The kinetic mechanism of the b ...

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Arch. Biochem. Biophys.

283

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Krishnaswamy

Use of monoclonal antibodies f ...

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Arch. Biochem. Biophys.

246

250-262

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Krishnaswamy

Ligand-induced interconversion ...

Zea mays

Arch. Biochem. Biophys.

222

449-463

1983

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Sainis

Localisation and characterisat ...

Hordeum vulgare, Pisum sativum

Planta

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1981

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Di Camelli

Comparison of sensitive and de ...

Zea mays

Plant Physiol.

65

176-183

1980

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246388

Grego

-

Comparison of homoserine dehyd ...

Pisum sativum, Ricinus communis, Triticum aestivum

Phytochemistry

19

1619-1623

1980

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Isolation and characterization ...

Zea mays

J. Biol. Chem.

254

1349-1355

1979

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Epstein

Homoserine dehydrogenase of Rh ...

Rhodospirillum rubrum

Eur. J. Biochem.

82

453-461

1978

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Ogilvie

Reaction of Tris with aldehyde ...

Escherichia coli

Biochim. Biophys. Acta

445

525-536

1976

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246391

Aarnes

-

Threonine-sensitive aspartate ...

Pisum sativum

Phytochemistry

13

2717-2724

1974

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Cavari

Properties of homoserine dehyd ...

Thermophilic bacterium

Biochim. Biophys. Acta

302

183-190

1973

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Saiki

Studies on homoserine dehydrog ...

Thermus thermophilus

J. Biochem.

74

1239-1248

1973

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