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Literature summary for 1.1.1.28 extracted from

  • Yao, P.; Cui, Y.; Yu, S.; Du, Y.; Feng, J.; Wu, Q.; Zhu, D.
    Efficient biosynthesis of (R)- or (S)-2-hydroxybutyrate from L-threonine through a synthetic biology approach (2016), Adv. Synth. Catal., 358, 2923-2928.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Staphylococcus epidermidis

Inhibitors

Inhibitors Comment Organism Structure
2-oxobutyrate substrate inhibition Staphylococcus epidermidis
additional information L-threonine and 2-hydroxybutyrate do not affect enzyme activity up to 200 mM Staphylococcus epidermidis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + NADH + H+ Staphylococcus epidermidis
-
(R)-lactate + NAD+
-
?
pyruvate + NADH + H+ Staphylococcus epidermidis ATCC 12228
-
(R)-lactate + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Staphylococcus epidermidis
-
-
-
Staphylococcus epidermidis ATCC 12228
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + NADH + H+
-
Staphylococcus epidermidis (R)-lactate + NAD+
-
?
pyruvate + NADH + H+
-
Staphylococcus epidermidis ATCC 12228 (R)-lactate + NAD+
-
?

Synonyms

Synonyms Comment Organism
D-lactate dehydrogenase
-
Staphylococcus epidermidis
D-LDH
-
Staphylococcus epidermidis

Cofactor

Cofactor Comment Organism Structure
NADH
-
Staphylococcus epidermidis