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Literature summary for 1.1.1.270 extracted from

  • Ferrante, T.; Adinolfi, S.; DArrigo, G.; Poirier, D.; Daga, M.; Lolli, M.L.; Balliano, G.; Spyrakis, F.; Oliaro-Bosso, S.
    Multiple catalytic activities of human 17beta-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors (2020), Biochimie, 170, 106-117 .
    View publication on PubMed
Search for more literature for 1.1.1.270

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli BL21 (DE3) Codon Plus RP cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(4-methyl)zymosterone + NADPH + H+ Homo sapiens cholesterol pathway (4-methyl)zymosterol + NADP+
-
 ?
dihydrotestosterone + NADPH + H+ Homo sapiens steroid hormone pathway 5alpha-androstane-3beta,17beta-diol + NADP+
-
 ?
progesterone + NADPH + H+ Homo sapiens steroid hormone pathway 4-pregnen-3beta-ol-20-one + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P56937
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(4-methyl)zymosterone + NADPH + H+
-
 Homo sapiens (4-methyl)zymosterol + NADP+
-
 ?
(4-methyl)zymosterone + NADPH + H+ cholesterol pathway Homo sapiens (4-methyl)zymosterol + NADP+
-
 ?
dihydrotestosterone + NADPH + H+
-
 Homo sapiens 5alpha-androstane-3beta,17beta-diol + NADP+
-
 ?
dihydrotestosterone + NADPH + H+ steroid hormone pathway Homo sapiens 5alpha-androstane-3beta,17beta-diol + NADP+
-
 ?
progesterone + NADPH + H+
-
 Homo sapiens 4-pregnen-3beta-ol-20-one + NADP+
-
 ?
progesterone + NADPH + H+ steroid hormone pathway Homo sapiens 4-pregnen-3beta-ol-20-one + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
HSD17B7
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is involved in the metabolism of steroid hormones and in the biosynthesis of cholesterol Homo sapiens