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Literature summary for 1.1.1.27 extracted from

  • Pizzuto, R.; Paventi, G.; Porcile, C.; Sarnataro, D.; Daniele, A.; Passarella, S.
    L-Lactate metabolism in HEP G2 cell mitochondria due to the L-lactate dehydrogenase determines the occurrence of the lactate/pyruvate shuttle and the appearance of oxaloacetate, malate and citrate outside mitochondria (2012), Biochim. Biophys. Acta, 1817, 1679-1690 .
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km values for pyruvate, NADH, (S)-lactate and NAD+ are measured in the solubilized mirochondrial Hep G2 fractions. They differ from the values measured in the cytosolic fractions Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion L-lactate dehydrogenase is restricted to the inner mitochondrial compartments Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactate + NAD+ Homo sapiens since the mitochondrial metabolism of (S)-lactate results in synthesis and export of oxaloacetate, malate and citrate into the extramitochondrial phase, an anaplerotic role for the mitochondrial (S)-lactate metabolism is proposed pyruvate + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + NAD+
-
 Homo sapiens pyruvate + NADH + H+
-
 r
(S)-lactate + NAD+ since the mitochondrial metabolism of (S)-lactate results in synthesis and export of oxaloacetate, malate and citrate into the extramitochondrial phase, an anaplerotic role for the mitochondrial (S)-lactate metabolism is proposed Homo sapiens pyruvate + NADH + H+
-
 r
pyruvate + NADH + H+
-
 Homo sapiens (S)-lactate + NAD+
-
 r

General Information

General Information Comment Organism
metabolism since the mitochondrial metabolism of (S)-lactate results in synthesis and export of oxaloacetate, malate and citrate into the extramitochondrial phase, an anaplerotic role for the mitochondrial (S)-lactate metabolism is proposed Homo sapiens