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Literature summary for 1.1.1.267 extracted from

  • Wang, C.; Lei, X.; Xia, J.; Wang, J.
    Effect of down-regulating 1-deoxy-D-xylulose-5-phosphate reductoisomerase by RNAi on growth and artemisinin biosynthesis in Artemisia annua L. (2018), Plant Growth Regul., 84, 549-559 .
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Protein Variants

Protein Variants Comment Organism
additional information DXR gene silencing by RNAi using Agrobacterium tumefaciens strain LBA4404, mutants phenotype, detailed analysis, overview. AaDXR-RNAi plants show no significant variation of stomatal length and density at the abaxial side of leaves. No significant alteration of floral initiation and flower opening is observed in the transgenic plants. The trichome density and area in leaves and flower buds are analyzed by fluorescence microscopy. It is evident that leaves of transgenic Artemisia annua in vegetative stage carry considerably lower density of trichomes than that of control. The trichome area of transgenic Artemisia annua is larger than that of control. During the flower formation, there is no difference of trichome density and area on flower bud surface between transgenic plants and control. Significant decline in chlorphylls Chla and Chlb is found in various growth stages of transgenic plants. Net photosynthesis rate of in DXRRNAi plants is decreased by 20.0-31.4% compared with that of the controls Artemisia annua

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Artemisia annua 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ Artemisia annua
-
 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Artemisia annua Q9SP64 cv. CQF39
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Artemisia annua
-
seedling
-
 Artemisia annua
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
-
 Artemisia annua 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
AaDXR
-
 Artemisia annua
DXR
-
 Artemisia annua
DXR1
-
 Artemisia annua

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Artemisia annua
NADPH
-
 Artemisia annua

General Information

General Information Comment Organism
metabolism 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), an important enzyme in the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway in plant plastids, provides the basic five-carbon units for isoprenoid biosynthesis. Roles of the MEP pathway in regulating growth, development, and artemisinin biosynthesis of Artemisia annua Artemisia annua