Literature summary for 1.1.1.265 extracted from

Hauser, M.; Horn, P.; Tournu, H.; Hauser, N.C.; Hoheisel, J.D.; Brown, A.J.; Dickinson, J.R.
A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase (2007), FEMS Yeast Res., 7, 84-92.

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Protein Variants

Protein Variants	Comment	Organism
additional information	creation of a knockout mutant that forms large, invasive filaments	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
isovaleraldehyde + NADPH + H+	Saccharomyces cerevisiae	important role in the suppression of filamentation in response to isoamyl alcohol/isovaleraldehyde	isoamyl alcohol + NADP+	-	r

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	wild type strains IWD72 and BY4741 and enzyme knockout mutants, knockout mutant forms large, invasive filaments, activity increases at 5-6 h of cultivation in the presence of 0.5% isoamyl alcohol and then quickly declines to become undetectable after 8 h	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
isovaleraldehyde + NADPH + H+	important role in the suppression of filamentation in response to isoamyl alcohol/isovaleraldehyde	Saccharomyces cerevisiae	isoamyl alcohol + NADP+	-	r
additional information	enzyme displays also NADPH dependent methylglyoxal reductase activity (EC 1.1.1.283)	Saccharomyces cerevisiae	?	-	?

Synonyms

Synonyms	Comment	Organism
GRE2 gene product	-	Saccharomyces cerevisiae
Gre2p	-	Saccharomyces cerevisiae
isovaleraldehyde reductase	-	Saccharomyces cerevisiae
More	enzyme displays also NADPH dependent methylglyoxal reductase activity (EC 1.1.1.283)	Saccharomyces cerevisiae
YOL151w gene product	-	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Saccharomyces cerevisiae
NADPH	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)