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Literature summary for 1.1.1.252 extracted from

  • Andersson, A.; Jordan, D.; Schneider, G.; Lindqvist, Y.
    Crystal structure of the ternary complex of 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea with NADPH and an active-site inhibitor (1996), Structure, 4, 1161-1170.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
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 Pyricularia grisea

Inhibitors

Inhibitors Comment Organism Structure
Tricyclazole binds at the active site in the vicinity of the NADPH nicotinamide ring Pyricularia grisea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,3,6,8-Tetrahydroxynaphthalene + NADPH Pyricularia grisea essential reaction in the biosynthesis of melanin Scytalone + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Pyricularia grisea
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,3,6,8-Tetrahydroxynaphthalene + NADPH
-
 Pyricularia grisea Scytalone + NADP+
-
 ?
1,3,6,8-Tetrahydroxynaphthalene + NADPH essential reaction in the biosynthesis of melanin Pyricularia grisea Scytalone + NADP+
-
 ?
1,3,8-trihydroxynaphthalene + NADPH + H+
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 Pyricularia grisea vermelone + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH coenzyme specificity is partly conferred by the interaction of a single basic residue, Arg39, with the 2' phosphate group of NADPH Pyricularia grisea