Literature summary for 1.1.1.25 extracted from

Barcellos, G.B.; Caceres, R.A.; de Azevedo, W.F.
Structural studies of shikimate dehydrogenase from Bacillus anthracis complexed with cofactor NADP (2009), J. Mol. Model., 15, 147-155.

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Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
30160	-	molecular modeling	Bacillus anthracis

Organism

Organism	UniProt	Comment	Textmining
Bacillus anthracis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-dehydroshikimate + NADPH + H+	structure of the enzyme is a compact alpha/beta sandwich with two distinct domains, responsible for binding substrate and NADP cofactor, respectively	Bacillus anthracis	shikimate + NADP+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	high affinity for the enzyme, the residues Gly130 and Ala131 are present in the N-terminal of the helix and those make positive electrostatic interactions with the phosphates of NADP cofactor	Bacillus anthracis

pI Value

Organism	Comment	pI Value Maximum	pI Value
Bacillus anthracis	molecular modeling	-	6.55

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Release 2023.1 (January 2023)