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Literature summary for 1.1.1.25 extracted from
- Shikimate dehydrogenase structure reveals novel fold (2003), Structure, 11, 902-903.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Methanocaldococcus jannaschii | fourth enzyme in the shikimate biosynthetic pathway | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanocaldococcus jannaschii | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | fourth enzyme in the shikimate biosynthetic pathway | Methanocaldococcus jannaschii | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the structure reveals an enzyme with a deep cleft, which contains the active site, formed at the junction of two domains. The C-terminal domain is easily recognizable as a Rossmann fold dinucleotide binding domain, responsible for binding the NADP cofactor. The N-terminal substrate binding and dimerization domain, an alpha-beta-alpha sandwich, represents a unique topological fold, structure modeling | Methanocaldococcus jannaschii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SDH | - |
Methanocaldococcus jannaschii |
| shikimate 5-dehydrogenase | - |
Methanocaldococcus jannaschii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | dinucleotide cofactor binding domain structure is a Rossmann fold | Methanocaldococcus jannaschii |
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Release 2023.1 (January 2023)
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