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Literature summary for 1.1.1.239 extracted from

  • Krazeisen, A.; Breitling, R.; M๖ller, G.; Adamski, J.
    Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5 (2001), Mol. Cell. Endocrinol., 171, 151-162.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
7-hydroxyflavone 0.007 mM, 50% inhibition, oxidation of androstandiol Homo sapiens
abietic acid 0.010 mM, 50% inhibition, oxidation of androstandiol Homo sapiens
biochain A 0.014 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.008 mM, oxidation of androstanediol Homo sapiens
chrysin 0.010 mM, 50% inhibition, oxidation of androstandiol Homo sapiens
coumestrol 0.005 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.011 mM, 50% inhibition, oxidation of androstanediol Homo sapiens
kaempferol 0.008 mM, 50% inhibition, oxidation of androstandiol Homo sapiens
naringenin 0.010 mM, 50% inhibition, oxidation of androstandiol Homo sapiens
quercetin 0.009 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.005 mM, oxidation of androstanediol Homo sapiens
zearalenone 0.004 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.002 mM, oxidation of androstanediol Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-dihydrotestosterone + NAD+ Homo sapiens
-
androstandione + NADH + H+
-
r
androstandiol + NAD+ Homo sapiens
-
androsterone + NADH
-
r
testosterone + NAD+ Homo sapiens
-
androst-4-ene-3,17-dione + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland in males Homo sapiens
-
corpus luteum
-
Homo sapiens
-
mammary gland
-
Homo sapiens
-
testis expressed in Leydig cells Homo sapiens
-
uterine endometrium in females Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-dihydrotestosterone + NAD+
-
Homo sapiens androstanedione + NADH + H+
-
r
5alpha-dihydrotestosterone + NAD+
-
Homo sapiens androstandione + NADH + H+
-
r
androstandiol + NAD+
-
Homo sapiens androsterone + NADH
-
r
androstanediol + NAD+
-
Homo sapiens androsterone + NADH
-
r
testosterone + NAD+
-
Homo sapiens androst-4-ene-3,17-dione + NADH + H+
-
r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens