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Literature summary for 1.1.1.23 extracted from

  • Pahwa, S.; Kaur, S.; Jain, R.; Roy, N.
    Structure based design of novel inhibitors for histidinol dehydrogenase from Geotrichum candidum (2010), Bioorg. Med. Chem. Lett., 20, 3972-3976.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
-
Geotrichum candidum
3-(1H-imidazol-4-yl)propanoic acid
-
Geotrichum candidum
5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid i.e. RJ-278 Geotrichum candidum
7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
-
Geotrichum candidum
methyl 1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate
-
Geotrichum candidum
methyl 1-methyl-N-(phenoxycarbonyl)histidinate
-
Geotrichum candidum
methyl 3-(1H-imidazol-4-yl)propanoate
-
Geotrichum candidum
methyl N-(methoxycarbonyl)histidinate
-
Geotrichum candidum
additional information screening of substrate analog inhibitors of histidinol dehydrogenase, and docking analysis of these antifungal agents, overview Geotrichum candidum

Organism

Organism UniProt Comment Textmining
Geotrichum candidum A1BPP9 gene hisD
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ligand-protein interactions in the active site of GcHDH, molecular docking, overview Geotrichum candidum ?
-
?

Subunits

Subunits Comment Organism
homodimer structure modelling, overview Geotrichum candidum
More Geotrichum candidum HIS4 protein has HIS4A, HIS4B, and HIS4C subregions Geotrichum candidum

Synonyms

Synonyms Comment Organism
GcHDH
-
Geotrichum candidum
HIS4 protein
-
Geotrichum candidum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00317
-
pH not specified in the publication, temperature not specified in the publication Geotrichum candidum 3-(1H-imidazol-4-yl)propanoic acid
0.00356
-
pH not specified in the publication, temperature not specified in the publication Geotrichum candidum 5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
0.0052
-
pH not specified in the publication, temperature not specified in the publication Geotrichum candidum methyl 3-(1H-imidazol-4-yl)propanoate
0.0106
-
pH not specified in the publication, temperature not specified in the publication Geotrichum candidum methyl N-(methoxycarbonyl)histidinate
0.0242
-
pH not specified in the publication, temperature not specified in the publication Geotrichum candidum 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
0.0293
-
pH not specified in the publication, temperature not specified in the publication Geotrichum candidum methyl 1-methyl-N-(phenoxycarbonyl)histidinate
0.0587
-
pH not specified in the publication, temperature not specified in the publication Geotrichum candidum 1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
0.1222
-
pH not specified in the publication, temperature not specified in the publication Geotrichum candidum methyl 1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate

General Information

General Information Comment Organism
metabolism histidinol dehydrogenase mediates the final step in the histidine biosynthetic pathway Geotrichum candidum