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Literature summary for 1.1.1.23 extracted from

  • Pahwa, S.; Chavan, A.G.; Jain, R.; Roy, N.
    Target-specific anti-fungal discovery by targeting Geotrichum candidum histidinol dehydrogenase: a hybrid approach (2008), Chem. Biol. Drug Des., 72, 229-234.
    View publication on PubMed

Application

Application Comment Organism
drug development histidinol dehydrogenase is a suitable target for not only for Geotrichum candidum but also for related species, wherby compounds identified can serve as a valuable lead for development of novel non-classical antifungal therapy, notably against strain like Candida rapidly becoming resistant to conventional therapy Geotrichum candidum

Cloned(Commentary)

Cloned (Comment) Organism
-
Geotrichum candidum

Inhibitors

Inhibitors Comment Organism Structure
(7R)-1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid weaker inhibitor Geotrichum candidum
7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one most active inhibitor Geotrichum candidum
imidazole-4-carboxylic acid most active inhibitor Geotrichum candidum
methyl (7R)-1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate weaker inhibitor Geotrichum candidum
methyl 3-(1H-imidazol-4-yl)propanoate
-
Geotrichum candidum
methyl N-(ethoxycarbonyl)-1-methyl-L-histidinate
-
Geotrichum candidum
methyl N-(methoxycarbonyl)-3-methyl-L-histidinate
-
Geotrichum candidum
additional information 5% dimethyl sulfoxide or methyl N-[(trifluoromethoxy)carbonyl]-L-histidinate trifluoroacetate fails to exert any growth inhibitory activity Geotrichum candidum

Organism

Organism UniProt Comment Textmining
Geotrichum candidum
-
-
-

Synonyms

Synonyms Comment Organism
HDH
-
Geotrichum candidum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0052
-
-
Geotrichum candidum methyl 3-(1H-imidazol-4-yl)propanoate
0.0064
-
-
Geotrichum candidum imidazole-4-carboxylic acid
0.0106
-
-
Geotrichum candidum methyl N-(methoxycarbonyl)-3-methyl-L-histidinate
0.0242
-
-
Geotrichum candidum 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
0.0293
-
-
Geotrichum candidum methyl N-(ethoxycarbonyl)-1-methyl-L-histidinate
0.0587
-
-
Geotrichum candidum (7R)-1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
0.1222
-
-
Geotrichum candidum methyl (7R)-1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate