Application | Comment | Organism |
---|---|---|
drug development | histidinol dehydrogenase is a suitable target for not only for Geotrichum candidum but also for related species, wherby compounds identified can serve as a valuable lead for development of novel non-classical antifungal therapy, notably against strain like Candida rapidly becoming resistant to conventional therapy | Geotrichum candidum |
Cloned (Comment) | Organism |
---|---|
- |
Geotrichum candidum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(7R)-1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid | weaker inhibitor | Geotrichum candidum | |
7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one | most active inhibitor | Geotrichum candidum | |
imidazole-4-carboxylic acid | most active inhibitor | Geotrichum candidum | |
methyl (7R)-1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate | weaker inhibitor | Geotrichum candidum | |
methyl 3-(1H-imidazol-4-yl)propanoate | - |
Geotrichum candidum | |
methyl N-(ethoxycarbonyl)-1-methyl-L-histidinate | - |
Geotrichum candidum | |
methyl N-(methoxycarbonyl)-3-methyl-L-histidinate | - |
Geotrichum candidum | |
additional information | 5% dimethyl sulfoxide or methyl N-[(trifluoromethoxy)carbonyl]-L-histidinate trifluoroacetate fails to exert any growth inhibitory activity | Geotrichum candidum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Geotrichum candidum | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
HDH | - |
Geotrichum candidum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0052 | - |
- |
Geotrichum candidum | methyl 3-(1H-imidazol-4-yl)propanoate | |
0.0064 | - |
- |
Geotrichum candidum | imidazole-4-carboxylic acid | |
0.0106 | - |
- |
Geotrichum candidum | methyl N-(methoxycarbonyl)-3-methyl-L-histidinate | |
0.0242 | - |
- |
Geotrichum candidum | 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one | |
0.0293 | - |
- |
Geotrichum candidum | methyl N-(ethoxycarbonyl)-1-methyl-L-histidinate | |
0.0587 | - |
- |
Geotrichum candidum | (7R)-1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid | |
0.1222 | - |
- |
Geotrichum candidum | methyl (7R)-1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate |