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Literature summary for 1.1.1.23 extracted from

  • Wadud, S.; Or-Rashid, M.M.; Onodera, R.
    Method for determination of histidine in tissues by isocratic high-performance liquid chromatography and its application to the measurement of histidinol dehydrogenase activity in six cattle organs (2002), J. Chromatogr. B, 767, 369-374.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidinal + NAD+ + H2O Bos taurus enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal L-histidine + NADH + H+
-
ir
L-histidinol + NAD+ Bos taurus enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal L-histidinal + NADH + H+
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ir

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+ also oxidizes L-histidinal Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
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Bos taurus
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liver highest activity Bos taurus
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additional information activity in the organs in descending order: liver, kidney, pancreas, spleen, skeletal muscle, small intestine Bos taurus
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pancreas
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Bos taurus
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skeletal muscle low activity Bos taurus
-
small intestine very low activity Bos taurus
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spleen low activity Bos taurus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
the activity of the enzyme in different tissues at different pH values, development of a determination method for quantification of L-histidinol and L-histidine using isocratic HPLC, overview Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidinal + NAD+ + H2O
-
Bos taurus L-histidine + NADH + H+
-
ir
L-histidinal + NAD+ + H2O enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal Bos taurus L-histidine + NADH + H+
-
ir
L-histidinol + NAD+
-
Bos taurus L-histidinal + NADH + H+
-
ir
L-histidinol + NAD+ enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal Bos taurus L-histidinal + NADH + H+
-
ir

Synonyms

Synonyms Comment Organism
HLDase
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Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
the activity of the enzyme in different tissues is differently regulated with respect to the pH value, overview Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
8 12
-
Bos taurus