Literature summary for 1.1.1.220 extracted from

Steinerstauch, P.; Wermuth, B.; Leimbacher, W.; Curtius, H.C.
Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase (1989), Biochem. Biophys. Res. Commun., 164, 1130-1136.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6-pyruvoyltetrahydropterin + NADPH	Homo sapiens	involved in de novo biosynthesis of tetrahydrobiopterin	6-lactoyl-5,6,7,8-tetrahydropterin + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	enzyme is identical to aldose reductase	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-nitrobenzaldehyde + NADPH	-	Homo sapiens	4-nitrobenzylalcohol + NADP+	-	?
6-pyruvoyltetrahydropterin + NADPH	-	Homo sapiens	6-lactoyl-5,6,7,8-tetrahydropterin + NADP+	-	?
6-pyruvoyltetrahydropterin + NADPH	involved in de novo biosynthesis of tetrahydrobiopterin	Homo sapiens	6-lactoyl-5,6,7,8-tetrahydropterin + NADP+	-	?
additional information	typical substrates of aldose reductase tested as substrates	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)