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Literature summary for 1.1.1.22 extracted from

  • Arnold, J.M.; Gu, F.; Ambati, C.R.; Rasaily, U.; Ramirez-Pena, E.; Joseph, R.; Manikkam, M.; San Martin, R.; Charles, C.; Pan, Y.; Chatterjee, S.S.; Den Hollander, P.; Zhang, W.; Nagi, C.; Sikora, A.G.; Rowley, D.; Putluri, N.; Zhang, X.H.; Karanam, B.; Mani, S.A.; Sreekumar, A.
    UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression (2020), Oncogene, 39, 3089-3101 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine shRNA-mediated knockdown of UGDH inhibits breast cancer invasion, colony formation, and tumor growth Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O60701
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-

Source Tissue

Source Tissue Comment Organism Textmining
breast
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 Homo sapiens
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MDA-MB-231 cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function in breast cancer cells, depletion of the hyaluronic acid precursor UDP-glucuronic acid is sufficient to inhibit several mesenchymal-like properties including cellular invasion and colony formation in vitro, as well as tumor growth and metastasis in vivo. Depletion of UDP-glucuronic acid alters the expression of PPAR-gamma target genes and increases PPAR-gamma DNA binding activity Homo sapiens