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Literature summary for 1.1.1.22 extracted from

  • Lin, L.H.; Chou, H.C.; Chang, S.J.; Liao, E.C.; Tsai, Y.T.; Wei, Y.S.; Chen, H.Y.; Lin, M.W.; Wang, Y.S.; Chien, Y.A.; Yu, X.R.; Chan, H.L.
    Targeting UDP-glucose dehydrogenase inhibits ovarian cancer growth and metastasis (2020), J. Cell. Mol. Med., 24, 11883-11902 .
    View publication on PubMed

Application

Application Comment Organism
medicine expression of UDP-glucose dehydrogenase is up-regulated in highly metastatic ovarian cancer TOV-21G cells, but not in normal adjacent tissue. RNAi-mediated silencing results in a significant decrease in metastatic ability in transwell migration, transwell invasion and wound healing assays. The knockdown of UGDH causes cell cycle arrest in the G0/G1 phase and induces a massive decrease of tumour formation rate in vivo. UGDH-depletion leads to the down-regulation of epithelial-mesenchymal transition-related markers as well as MMP2, and inactivation of the ERK/MAPK pathway Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O60701
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Source Tissue

Source Tissue Comment Organism Textmining
TOV-21G cell
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Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens expression of UDP-glucose dehydrogenase is up-regulated in highly metastatic ovarian cancer TOV-21G cells up