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Literature summary for 1.1.1.22 extracted from

  • Teoh, S.T.; Ogrodzinski, M.P.; Lunt, S.Y.
    UDP-glucose 6-dehydrogenase knockout impairs migration and decreases in vivo metastatic ability of breast cancer cells (2020), Cancer Lett., 492, 21-30 .
    View publication on PubMed
Search for more literature for 1.1.1.22

Application

Application Comment Organism
medicine high UGDH expression is associated with decreased patient survival in poor-prognosis breast cancer subsets Homo sapiens
medicine knocking out UGDH in highly metastatic 6DT-1 breast cancer cells impairs migration ability without affecting in vitro proliferation. UGDH-KO results in significantly decreased metastatic capacity in vivo when the cells are orthotopically injected in syngeneic mice Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens O60701
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Mus musculus O70475
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Source Tissue

Source Tissue Comment Organism Textmining
4T1 cell
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 Mus musculus
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6DT1 cell
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 Mus musculus
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MVT-1 cell
-
 Mus musculus
-

General Information

General Information Comment Organism
physiological function knocking out UGDH in highly metastatic 6DT-1 breast cancer cells impairs migration ability without affecting in vitro proliferation. UGDH-KO results in significantly decreased metastatic capacity in vivo when the cells are orthotopically injected in syngeneic mice Mus musculus