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Literature summary for 1.1.1.22 extracted from

  • Vitale, D.L.; Caon, I.; Parnigoni, A.; Sevic, I.; Spinelli, F.M.; Icardi, A.; Passi, A.; Vigetti, D.; Alaniz, L.
    Initial identification of UDP-glucose dehydrogenase as a prognostic marker in breast cancer patients, which facilitates epirubicin resistance and regulates hyaluronan synthesis in MDA-MB-231 cells (2021), Biomolecules, 11, 246 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine epirubicin accumulation increases and apoptosis decreases during UGDH knockdown. Hyaluronan-coated matrix increases and a positive modulation of autophagy is detected. Higher levels of UGDH are correlated with worse prognosis in triple-negative breast cancer patients that receive chemotherapy. High expression of UGDH is found in tumoral tissue from HER2--patients. UGDH knockdown contributes to epirubicin resistance Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O60701
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Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function epirubicin accumulation increases and apoptosis decreases during UGDH knockdown. Hyaluronan-coated matrix increases and a positive modulation of autophagy is detected. Higher levels of UGDH are correlated with worse prognosis in triple-negative breast cancer patients that receive chemotherapy. High expression of UGDH is found in tumoral tissue from HER2--patients. UGDH knockdown contributes to epirubicin resistance Homo sapiens