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Literature summary for 1.1.1.22 extracted from

  • Klinghammer, M.; Tenhaken, R.
    Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls (2007), J. Exp. Bot., 58, 3609-3621.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of isoforms Ugd2, Ugd3, Ugd4 in Escherichia coli Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
UDP-xylose
-
Arabidopsis thaliana

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.042
-
NAD+ isoform Ugd3, pH 8.7, 22°C Arabidopsis thaliana
0.043
-
NAD+ isoform Ugd2, pH 8.7, 22°C Arabidopsis thaliana
0.044
-
NAD+ isoform Ugd4, pH 8.7, 22°C Arabidopsis thaliana
0.123
-
UDP-glucose isoform Ugd2, pH 8.7, 22°C Arabidopsis thaliana
0.171
-
UDP-glucose isoform Ugd4, pH 8.7, 22°C Arabidopsis thaliana
0.335
-
UDP-glucose isoform Ugd3, pH 8.7, 22°C Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no substrate: ADP-glucose, TDP-glucose Arabidopsis thaliana ?
-
?
UDP-glucose + 2 NAD+ + H2O
-
Arabidopsis thaliana UDP-glucuronate + 2 NADH + 2 H+
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.17
-
UDP-glucose isoform Ugd4, pH 8.7, 22°C Arabidopsis thaliana
1.92
-
UDP-glucose isoform Ugd2, pH 8.7, 22°C Arabidopsis thaliana
2.53
-
UDP-glucose isoform Ugd3, pH 8.7, 22°C Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NAD+ activity with NADP+ is about 20% of that with NAD+ Arabidopsis thaliana
NADP+ activity with NADP+ is about 20% of that with NAD+ Arabidopsis thaliana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.083
-
UDP-xylose isoform Ugd2, pH 8.7, 22°C Arabidopsis thaliana
0.16
-
UDP-xylose isoform Ugd3, pH 8.7, 22°C Arabidopsis thaliana
0.22
-
UDP-xylose isoform Ugd4, pH 8.7, 22°C Arabidopsis thaliana