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Literature summary for 1.1.1.22 extracted from

  • Vigetti, D.; Ori, M.; Viola, M.; Genasetti, A.; Karousou, E.; Rizzi, M.; Pallotti, F.; Nardi, I.; Hascall, V.C.; De Luca, G.; Passi, A.
    Molecular cloning and characterization of UDP-glucose dehydrogenase from the amphibian Xenopus laevis and its involvement in hyaluronan synthesis (2006), J. Biol. Chem., 281, 8254-8263.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
overexpression of the enzyme from Xenopus laevis in human smooth muscle cells increases the accumulation of hyaluronan Xenopus laevis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
 NAD+
-
 Xenopus laevis
0.9
-
 UDP-glucose
-
 Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + 2 NAD+ + H2O Xenopus laevis the enzyme has a crucial role during development of Xenopus laevis. Silencing of UGDH decreases glycosaminoglycan synthesis causing severe embryonic malformations because of defective gastrulation process UDP-glucuronate + 2 NADH + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Xenopus laevis Q56R95
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Xenopus laevis

Source Tissue

Source Tissue Comment Organism Textmining
embryo silencing of UGDH decreases glycosaminoglycan synthesis causing severe embryonic malformations because of defective gastrulation process. Overexpression of the enzyme from Xenopus laevis in human smooth muscle cells increases the accumulation of hyaluronan Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + 2 NAD+ + H2O
-
 Xenopus laevis UDP-glucuronate + 2 NADH + 2 H+
-
 ?
UDP-glucose + 2 NAD+ + H2O the enzyme has a crucial role during development of Xenopus laevis. Silencing of UGDH decreases glycosaminoglycan synthesis causing severe embryonic malformations because of defective gastrulation process Xenopus laevis UDP-glucuronate + 2 NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
UGDH
-
 Xenopus laevis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Xenopus laevis