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Literature summary for 1.1.1.214 extracted from

  • Wang, J.; Cheng, P.; Wu, Y.; Wang, A.; Liu, F.; Pei, X.
    Discovery of a new NADPH-dependent aldo-keto reductase from Candida orthopsilosis catalyzing the stereospecific synthesis of (R)-pantolactone by genome mining (2019), J. Biotechnol., 291, 26-34 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Candida orthopsilosis

Crystallization (Commentary)

Crystallization (Comment) Organism
homology modeling of structure and docking analysis. Structure reveals a triosephosphate isomerase barrel fold comprised of eight beta-strands and eight alpha-helices Candida orthopsilosis

Inhibitors

Inhibitors Comment Organism Structure
Ag+ 1 mM, complete inhibition Candida orthopsilosis
Co2+ 1 mM, 81.9% residual activity Candida orthopsilosis
Cu2+ 1 mM, 67.8% residual activity Candida orthopsilosis
EDTA 1 mM, 72.9% residual activity Candida orthopsilosis
Fe2+ 1 mM, 81% residual activity Candida orthopsilosis
Mg2+ 1 mM, 67.6% residual activity; 1 mM, 80.2% residual activity Candida orthopsilosis
additional information not inhibitory: 1 mM Ni2+ or Ca2+ Candida orthopsilosis
Pb2+ 1 mM, complete inhibition Candida orthopsilosis
Zn2+ 1 mM, 71.7% residual activity Candida orthopsilosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3
-
2-dehydropantolactone pH 7, 30°C Candida orthopsilosis

Organism

Organism UniProt Comment Textmining
Candida orthopsilosis H8XA83
-
-
Candida orthopsilosis 90-125 H8XA83
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-dehydropantolactone + NADPH + H+
-
Candida orthopsilosis (R)-pantolactone + NADP+
-
?

Subunits

Subunits Comment Organism
? x * 37000, SDS-PAGE and calculated from sequence Candida orthopsilosis

Synonyms

Synonyms Comment Organism
CORT_0G03830
-
Candida orthopsilosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
-
Candida orthopsilosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Candida orthopsilosis

pH Range

pH Minimum pH Maximum Comment Organism
6 8 more than 40% of maximum activity Candida orthopsilosis