Cloned (Comment) | Organism |
---|---|
overexpression of AKR1C9 in Escherichia coli | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
cytoplasm | - |
Rattus norvegicus | 5737 | - |
additional information | tissue-dependent subcellular localization, overview | Homo sapiens | - |
- |
additional information | tissue-dependent subcellular localization, overview | Rattus norvegicus | - |
- |
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Rattus norvegicus | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
37000 | - |
x * 37000, SDS-PAGE | Rattus norvegicus |
74000 | 75000 | native PAGE, kidney enzyme | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | AKR1C3 catalyzes androgen, estrogen, and prostaglandin metabolism, AKR1C3 is also involved in cancer development or progression | ? | - |
? | |
additional information | Rattus norvegicus | AKR1C9 catalyzes androgen, estrogen, and prostaglandin metabolism | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder | - |
Rattus norvegicus | - |
bladder | the urothelial epithelium lining the renal pelvis is strongly immunoreactive, but stromal cells in the underlying supporting connective tissue are negative | Homo sapiens | - |
epididymis | no activity in the stromal cells or endothelial cells, but weak immunoreactivity in the epididymal epithelial cells | Rattus norvegicus | - |
epididymis | only a small number of epithelial cells are immunoreactive with both nuclear and cytoplasmic reactivity | Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
epithelial cell | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
kidney | in renal cortex, endothelial cells of the glomeruli lack immunoreactivity for AKR1C3, but the Bowmans capsule and mesangial cells are strongly reactive, as well as larger epithelial cells of the medulla, overview | Homo sapiens | - |
additional information | tissue distribution of AKR1C3, immunohistochemic analysis, overview | Homo sapiens | - |
additional information | tissue distribution of AKR1C9, immunohistochemic analysis, overview | Rattus norvegicus | - |
prostate | - |
Homo sapiens | - |
prostate gland | epithelial cells, but not the stromal cells or endothelial cells | Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
testis | in Leydig cells, but no or poor activity in germ cells and Sertoli cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | AKR1C3 catalyzes androgen, estrogen, and prostaglandin metabolism, AKR1C3 is also involved in cancer development or progression | Homo sapiens | ? | - |
? | |
additional information | AKR1C9 catalyzes androgen, estrogen, and prostaglandin metabolism | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 37000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
AKR1C3 | - |
Homo sapiens |
AKR1C9 | - |
Rattus norvegicus |
More | cf. EC 1.1.1.50 | Homo sapiens |
More | cf. EC 1.1.1.50 | Rattus norvegicus |
type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |