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Literature summary for 1.1.1.213 extracted from
- 3-ketosteroid reductase activity and expression by fetal rat osteoblasts (2007), J. Biol. Chem., 282, 34003-34012.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | prostaglandin E2 increases AKR1C9 gene promoter activity and mRNA expression, AKR1C9 promoter activity is also enhanced by overexpression of protein kinase A catalytic subunit or transcription factor C/EBPdelta, whicb is reduced by dominant negative C/EBPdelta competition or C/EBPdelta antisense expression, overview | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression and promoter activity analysis, genetic enzyme regulation, overview | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 tibolone + 2 NADPH + 2 H+ | Rattus norvegicus | i.e. tibolone, a 3-ketosteroid androgen receptor, conversion to potent estrogen receptor alpha agonists, tibolone induces estrogen receptor alpha-dependent gene promoter activity through cis-acting estrogen response elements, increases the stimulatory effect of TGF-beta on Smad-dependent gene promoter activity, and enhances prostaglandin E2-induced activity of transcription factor Runx2, overview | 3alpha-hydroxytibolone + 3beta-hydroxytibolone + 2 NADP+ | 3alpha-hydroxytibolone is the primary metabolite | r |  |
| additional information | Rattus norvegicus | C/EBPdelta regulates the AKR1C9 gene promoter in osteoblasts, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P23457 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fetus | - |
Rattus norvegicus | - |
| osteoblast | fetal | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 tibolone + 2 NADPH + 2 H+ | i.e. tibolone, a 3-ketosteroid androgen receptor, conversion to potent estrogen receptor alpha agonists, tibolone induces estrogen receptor alpha-dependent gene promoter activity through cis-acting estrogen response elements, increases the stimulatory effect of TGF-beta on Smad-dependent gene promoter activity, and enhances prostaglandin E2-induced activity of transcription factor Runx2, overview | Rattus norvegicus | 3alpha-hydroxytibolone + 3beta-hydroxytibolone + 2 NADP+ | 3alpha-hydroxytibolone is the primary metabolite | r | |
| 2 tibolone + 2 NADPH + 2 H+ | i.e. tibolone, a 3-ketosteroid androgen receptor, conversion to potent estrogen receptor alpha agonists, overview | Rattus norvegicus | 3alpha-hydroxytibolone + 3beta-hydroxytibolone + 2 NADP+ | 3alpha-hydroxytibolone is the primary metabolite | r | |
| additional information | C/EBPdelta regulates the AKR1C9 gene promoter in osteoblasts, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AKR1C9 | - |
Rattus norvegicus |
| More | the enzyme belongs to the aldo-keto reductase gene family | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Rattus norvegicus | |
| NADPH | - |
Rattus norvegicus | |
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