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Literature summary for 1.1.1.21 extracted from

  • D'Andrea, F.; Sartini, S.; Piano, I.; Franceschi, M.; Quattrini, L.; Guazzelli, L.; Ciccone, L.; Orlandini, E.; Gargini, C.; La Motta, C.; Nencetti, S.
    Oxy-imino saccharidic derivatives as a new structural class of aldose reductase inhibitors endowed with anti-oxidant activity (2020), J. Enzyme Inhib. Med. Chem., 35, 1194-1205 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
((3aR,4R,6S,6aR)-6-((Z)-(((4-hydroperoxybenzyl)oxy)imino)methyl)-4-hydroxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 3-chlorobenzoate 83% inhibition at 0.1 mM, oxyimino derivative, obtained by reaction of a 1,5-dicarbonyl substrate with O-(arylmethyl)hydroxylamine. Inhibitor reduces both cell death and the apoptotic process when tested in an in vitro model of diabetic retinopathy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15121
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