Literature summary for 1.1.1.21 extracted from

Hmimid, F.; Lahlou, F.; Guenaou, I.; Nait Irahal, I.; Errami, A.; Fahde, S.; Bourhim, N.
Purification and characterization of aldose reductase from jerboa (Jaculus orientalis) and evaluation of its inhibitory activity by Euphorbia regis-jubae (Webb & Berth) extracts (2021), Comp. Biochem. Physiol. C Toxicol. Pharmacol., 244, 109001 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
Euphorbia regis-jubae aqueous extract	-	Jaculus orientalis
Euphorbia regis-jubae hydroethanolic extract	-	Jaculus orientalis

Organism

Organism	UniProt	Comment	Textmining
Jaculus orientalis	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
purification from kidney of prehibernating jerboas	Jaculus orientalis

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	highest enzyme activity is detected in the kidneys, followed by white adipose tissue and the lungs of prehibernating jerboa	Jaculus orientalis	-
lung	highest enzyme activity is detected in the kidneys, followed by white adipose tissue and the lungs of prehibernating jerboa	Jaculus orientalis	-
white adipose tissue	highest enzyme activity is detected in the kidneys, followed by white adipose tissue and the lungs of prehibernating jerboa	Jaculus orientalis	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glyceraldehyde + NAD(P)H + H+	-	Jaculus orientalis	glycerol + NAD(P)+	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
35	-	-	Jaculus orientalis

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.5	7.5	-	Jaculus orientalis

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	IC50 value is 140 microg/ml	Jaculus orientalis	Euphorbia regis-jubae aqueous extract
additional information	-	IC50 value is 96 microg/ml	Jaculus orientalis	Euphorbia regis-jubae hydroethanolic extract

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Release 2023.1 (January 2023)